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NCT07528404
High-Flow Nasal Cannula After Major Abdominal Surgery to Prevent Postoperative Pulmonary Complications
NA trial testing High flow nasal cannula (HFNC) in Postoperative Complications in 580 participants. Not yet recruiting.
31 December 2027
Quick facts
| Lead sponsor | Uijeongbu St. Mary Hospital |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 580 |
| Start date | 1 July 2026 |
| Primary completion | 31 December 2027 |
| Estimated completion | 31 December 2027 |
| Sites | 1 location across South Korea |
Drugs / interventions tested
- High flow nasal cannula (HFNC)
- Standard oxygen therapy
Conditions studied
- Postoperative Complications — all drugs for Postoperative Complications →
- Atelectasis — all drugs for Atelectasis →
- Pneumonia — all drugs for Pneumonia →
- Respiratory Insufficiency — all drugs for Respiratory Insufficiency →
Sponsor
Uijeongbu St. Mary Hospital
Who can join
19 and older, any sex, with Postoperative Complications or Atelectasis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Major abdominal surgery is associated with a substantial risk of early postoperative pulmonary complications, including atelectasis, hypoxemia, pneumonia, and increased need for respiratory support. High-flow nasal cannula (HFNC) provides warmed and humidified oxygen at high flow rates and may improve oxygenation, reduce respiratory workload, and support lung volume during the immediate postoperative period. However, whether routine prophylactic HFNC after major abdominal surgery reduces clinically significant postoperative pulmonary complications remains uncertain. This prospective, single-center, randomized controlled trial will evaluate whether prophylactic HFNC applied for 24 hours immediately after extubation reduces postoperative pulmonary complications compared with standard postoperative respiratory care in adult patients undergoing major abdominal surgery under general anesthesia with an actual anesthetic duration of 3 hours or longer.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07528404
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of High flow nasal cannula (HFNC)
Trials testing the same drug.
- NCT05499039 — High Flow Nasal Cannula Versus Non-Invasive (NIV)in Both Hypoxemic and Hypercapnic Respiratory Failure. · NA · unknown
- NCT04715243 — Comparison of High Flow Nasal Cannula (HFNC), Face-mask Non-Invasive Ventilation (NIV) & Helmet NIV in COVID-19 ARDS Pat · NA · terminated
- NCT05809089 — HFNO in Pneumonia Patients Presenting With Acute Hypoxemic Respiratory Failure · NA · completed
- NCT05075668 — Efficacy of HFNC as an Alternative to CPAP Therapy in Surgical Patients With Suspected Moderate to Severe OSA · NA · completed
- NCT02662387 — External Nasal Dilator and Oxygen Therapy in Respiratory Failure · NA · completed
Other recruiting trials for Postoperative Complications
Currently open trials in the same condition.
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- NCT07388108 — Atrial Dyssynchrony to Predict Arrhythmias in the Postoperative Setting of Cardiovascular Surgery. · recruiting
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- NCT07349719 — Dynamic Compliance-Guided Ventilation in Lumbar Surgery · NA · recruiting
Other Uijeongbu St. Mary Hospital trials
Trials by the same sponsor.
- NCT04234412 — Treatment of Osteoarthritic Knee With High Tibial Osteotomy and Implantation of Allogenic Human Umbilical Cord Blood-der · NA · unknown
- NCT03615300 — Predicting Long-term Outcomes After Cardiac Arrest by Using Serum NGAL · terminated
- NCT03175965 — Prognostic Value of P30 After Cardiac Arrest · completed
- NCT03236610 — Tenofovir Monotherapy in Patients With Chronic Hepatitis B Patients Who Had Achieved Complete Viral Suppression on Entec · Phase 3 · unknown
- NCT03236584 — Tenofovir Monotherapy in Patients With Chronic Hepatitis B Patients Who Had Achieved Complete Viral Suppression on Lamiv · Phase 3 · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07528404 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Uijeongbu St. Mary Hospital
- Last refreshed: 14 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07528404.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing