Last reviewed · How we verify
NCT07475871: TOURNI-PAIN
Tourniquet Exposure and Risk of Chronic Pain After Severe Limb Trauma
trial in Pain in 150 participants. Not yet recruiting.
15 March 2026
Quick facts
| Lead sponsor | Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans) |
|---|---|
| Status | Not yet recruiting |
| Study type | OBSERVATIONAL |
| Enrollment | 150 |
| Start date | 15 March 2026 |
| Primary completion | 15 March 2026 |
| Estimated completion | 15 March 2026 |
| Sites | 1 location across Ukraine |
Conditions studied
- Pain — all drugs for Pain →
- Pain After Surgery — all drugs for Pain After Surgery →
- Phantom Limb Pain After Amputation — all drugs for Phantom Limb Pain After Amputation →
- Military Combat Stress Reaction — all drugs for Military Combat Stress Reaction →
Sponsor
Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans) — full company profile →
Who can join
Adults 18 to 60, any sex, with Pain or Pain After Surgery. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Severe limb trauma often requires the use of a tourniquet to stop life-threatening bleeding. While tourniquets are essential for saving lives, prolonged interruption of blood flow may lead to tissue ischemia, nerve injury, and inflammatory responses that could contribute to the development of chronic pain. The TOURNI-PAIN Study is a prospective observational study designed to investigate whether the duration of tourniquet use during the treatment of severe limb injuries is associated with an increased risk of persistent pain after recovery. The study will enroll adult patients with major upper or lower limb trauma who required tourniquet application in the prehospital or hospital setting. Researchers will collect information about the duration and characteristics of tourniquet use, details of the injury, surgical treatment, and recovery. Participants will be followed for up to 6 months after injury to assess pain levels, possible neuropathic pain, functional recovery, and quality of life. The goal of this research is to better understand whether longer tourniquet exposure increases the risk of long-term pain. The findings may help improve trauma care practices by balancing the life-saving benefits of hemorrhage control with strategies that minimize long-term complications and improve recovery for patients with severe limb injuries.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07475871
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans) trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07475871 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
- Last refreshed: 18 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07475871.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing