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NCT07382453
Effect of PAE Hydrogel Loaded With tRF-ASO-Exo on Patients With Diabetic Ocular Surface Diseases
Phase 2 trial testing Exosomes in Diabetic Keratopathy in 30 participants. Not yet recruiting.
30 December 2028
Quick facts
| Lead sponsor | Affiliated Hospital of Nantong University |
|---|---|
| Phase | Phase 2 |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 30 |
| Start date | 15 February 2026 |
| Primary completion | 30 December 2028 |
| Estimated completion | 30 June 2029 |
Drugs / interventions tested
- Exosomes
- tRNA-derived fragments-antisense oligonucleotides-exosomes — full drug profile →
- poly（β-amino ester）hydrogel loaded with tRNA-derived fragments-antisense oligonucleotides-exosomes — full drug profile →
Conditions studied
- Diabetic Keratopathy — all drugs for Diabetic Keratopathy →
Sponsor
Affiliated Hospital of Nantong University
Who can join
Adults 18 to 70, any sex, with Diabetic Keratopathy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is to determine whether poly（β-amino ester）(PAE)hydrogel loaded with tRNA-derived fragments-antisense oligonucleotides-exosomes(tRF-ASO-Exo) could alleviate symptoms in patients with diabetic ocular surface diseases(DOSD).
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Hit the bull's eye: Engineered extracellular vesicles for targeted therapy.
Cai Y, Zhang H, Fan X, Fu H, et al · · 2026 · PMID 42164998 · DOI 10.1016/j.bioactmat.2026.04.035
Verify or expand the search:
- PubMed search for NCT07382453
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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Other Affiliated Hospital of Nantong University trials
Trials by the same sponsor.
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- NCT07247838 — Prospective Cohort Control Study on Changes in Gut Microbiota in Ischemic Stroke · recruiting
- NCT07271147 — Effects of taVNS Combined With Dexmedetomidine on POVN · NA · recruiting
- NCT07375667 — Dynamic Airway Resistance & ML: Guide Sputum Suction in Ventilated Patients · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07382453 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Affiliated Hospital of Nantong University
- Last refreshed: 4 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07382453.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing