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NCT07375667
Dynamic Airway Resistance & ML: Guide Sputum Suction in Ventilated Patients
NA trial testing The dynamics of airway resistance in Mechanical Ventilation Pressure High in 258 participants. Currently enrolling.
30 December 2028
Quick facts
| Lead sponsor | Affiliated Hospital of Nantong University |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | single |
| Primary purpose | supportive care |
| Enrollment | 258 |
| Start date | 30 October 2025 |
| Primary completion | 30 December 2028 |
| Estimated completion | 30 December 2029 |
| Sites | 3 locations across China |
Drugs / interventions tested
- The dynamics of airway resistance
- conventional suctioning
Conditions studied
- Mechanical Ventilation Pressure High — all drugs for Mechanical Ventilation Pressure High →
- Ventilator-Associated Pneumonia (VAP) — all drugs for Ventilator-Associated Pneumonia (VAP) →
- Respiratory Depression Neonatal — all drugs for Respiratory Depression Neonatal →
Sponsor
Affiliated Hospital of Nantong University
Who can join
Adults 18 to 90, any sex, with Mechanical Ventilation Pressure High or Ventilator-Associated Pneumonia (VAP). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Research has shown that timely suctioning not only improves survival rates but also enhances the quality of life in ventilator-dependent patients. However, clinical judgment on the optimal timing for suctioning currently relies primarily on physician experience, lacking scientific evidence \[10\]. Airway viscous resistance reflects the frictional resistance encountered by gas flow within the airways and is closely associated with airway patency. When airway secretions increase, viscous resistance undergoes dynamic changes. Therefore, analyzing these dynamic variations in viscous resistance derived from ventilator waveforms to determine the optimal suctioning timing and assess its clinical impact on the progression of pulmonary inflammation holds significant scientific value and offers new insights and methodologies for clinical practice.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07375667
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Mechanical Ventilation Pressure High
Currently open trials in the same condition.
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Other Affiliated Hospital of Nantong University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07375667 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Affiliated Hospital of Nantong University
- Last refreshed: 29 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07375667.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing