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NCT04202783

The Use of Exosomes In Craniofacial Neuralgia

Suspended NA Last updated 28 September 2022
What this trial tests

NA trial testing Exosomes in Neuralgia in 100 participants. Suspended.

Timeline
1 December 2023
Primary endpoint
1 December 2024
1 December 2024

Quick facts

Lead sponsorNeurological Associates of West Los Angeles
PhaseNA
StatusSuspended
Study typeINTERVENTIONAL
Allocationna
Designsingle group
Maskingnone
Primary purposetreatment
Enrollment100
Start date1 December 2023
Primary completion1 December 2024
Estimated completion1 December 2024
Sites1 location across United States

Drugs / interventions tested

Conditions studied

Sponsor

Neurological Associates of West Los Angeles

Who can join

18 and older, any sex, with Neuralgia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study is designed to evaluate the safety and efficacy of exosome deployment in patients with Craniofacial Neuralgia. Secondarily, this study is designed to rigorously evaluate for any adverse events that may be related to the administration and reception of exosomes.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Clinical applications of stem cell-derived exosomes.
    Tan F, Li X, Wang Z, Li J, et al · · 2024 · cited 390× · PMID 38212307 · DOI 10.1038/s41392-023-01704-0
  2. Exosomes─Nature's Lipid Nanoparticles, a Rising Star in Drug Delivery and Diagnostics.
    Tenchov R, Sasso JM, Wang X, Liaw WS, et al · · 2022 · cited 336× · PMID 36354238 · DOI 10.1021/acsnano.2c08774
  3. Current Knowledge and Future Perspectives on Mesenchymal Stem Cell-Derived Exosomes as a New Therapeutic Agent.
    Joo HS, Suh JH, Lee HJ, Bang ES, et al · · 2020 · cited 206× · PMID 31979113 · DOI 10.3390/ijms21030727
  4. High-Intensity Focused Ultrasound: A Review of Mechanisms and Clinical Applications.
    Bachu VS, Kedda J, Suk I, Green JJ, et al · · 2021 · cited 166× · PMID 34374945 · DOI 10.1007/s10439-021-02833-9
  5. Potential Use of Exosomes as Diagnostic Biomarkers and in Targeted Drug Delivery: Progress in Clinical and Preclinical Applications.
    Huda MN, Nafiujjaman M, Deaguero IG, Okonkwo J, et al · · 2021 · cited 160× · PMID 33988964 · DOI 10.1021/acsbiomaterials.1c00217
  6. Therapeutic Features and Updated Clinical Trials of Mesenchymal Stem Cell (MSC)-Derived Exosomes.
    Lee BC, Kang I, Yu KR. · · 2021 · cited 124× · PMID 33670202 · DOI 10.3390/jcm10040711
  7. Cell-derived nanovesicle-mediated drug delivery to the brain: Principles and strategies for vesicle engineering.
    Liang Y, Iqbal Z, Lu J, Wang J, et al · · 2023 · cited 99× · PMID 36245129 · DOI 10.1016/j.ymthe.2022.10.008
  8. Functional assays to assess the therapeutic potential of extracellular vesicles.
    Nguyen VVT, Witwer KW, Verhaar MC, Strunk D, et al · · 2020 · cited 94× · PMID 33708360 · DOI 10.1002/jev2.12033

Verify or expand the search:

Other trials of Exosomes

Trials testing the same drug.

Other recruiting trials for Neuralgia

Currently open trials in the same condition.

Other Neurological Associates of West Los Angeles trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

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