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NCT04202783
The Use of Exosomes In Craniofacial Neuralgia
NA trial testing Exosomes in Neuralgia in 100 participants. Suspended.
1 December 2024
Quick facts
| Lead sponsor | Neurological Associates of West Los Angeles |
|---|---|
| Phase | NA |
| Status | Suspended |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 100 |
| Start date | 1 December 2023 |
| Primary completion | 1 December 2024 |
| Estimated completion | 1 December 2024 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Exosomes
Conditions studied
- Neuralgia — all drugs for Neuralgia →
Sponsor
Neurological Associates of West Los Angeles
Who can join
18 and older, any sex, with Neuralgia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study is designed to evaluate the safety and efficacy of exosome deployment in patients with Craniofacial Neuralgia. Secondarily, this study is designed to rigorously evaluate for any adverse events that may be related to the administration and reception of exosomes.
Publications & conference data
8 peer-reviewed publications reference this trial (live from Europe PMC):
-
Clinical applications of stem cell-derived exosomes.
Tan F, Li X, Wang Z, Li J, et al · · 2024 · cited 390× · PMID 38212307 · DOI 10.1038/s41392-023-01704-0 -
Exosomes─Nature's Lipid Nanoparticles, a Rising Star in Drug Delivery and Diagnostics.
Tenchov R, Sasso JM, Wang X, Liaw WS, et al · · 2022 · cited 336× · PMID 36354238 · DOI 10.1021/acsnano.2c08774 -
Current Knowledge and Future Perspectives on Mesenchymal Stem Cell-Derived Exosomes as a New Therapeutic Agent.
Joo HS, Suh JH, Lee HJ, Bang ES, et al · · 2020 · cited 206× · PMID 31979113 · DOI 10.3390/ijms21030727 -
High-Intensity Focused Ultrasound: A Review of Mechanisms and Clinical Applications.
Bachu VS, Kedda J, Suk I, Green JJ, et al · · 2021 · cited 166× · PMID 34374945 · DOI 10.1007/s10439-021-02833-9 -
Potential Use of Exosomes as Diagnostic Biomarkers and in Targeted Drug Delivery: Progress in Clinical and Preclinical Applications.
Huda MN, Nafiujjaman M, Deaguero IG, Okonkwo J, et al · · 2021 · cited 160× · PMID 33988964 · DOI 10.1021/acsbiomaterials.1c00217 -
Therapeutic Features and Updated Clinical Trials of Mesenchymal Stem Cell (MSC)-Derived Exosomes.
Lee BC, Kang I, Yu KR. · · 2021 · cited 124× · PMID 33670202 · DOI 10.3390/jcm10040711 -
Cell-derived nanovesicle-mediated drug delivery to the brain: Principles and strategies for vesicle engineering.
Liang Y, Iqbal Z, Lu J, Wang J, et al · · 2023 · cited 99× · PMID 36245129 · DOI 10.1016/j.ymthe.2022.10.008 -
Functional assays to assess the therapeutic potential of extracellular vesicles.
Nguyen VVT, Witwer KW, Verhaar MC, Strunk D, et al · · 2020 · cited 94× · PMID 33708360 · DOI 10.1002/jev2.12033
Verify or expand the search:
- PubMed search for NCT04202783
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Exosomes
Trials testing the same drug.
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- NCT07565844 — Intradermal Exosomes, Platelet-Rich Plasma, and Steroids for Post-Herpetic Neuralgia · NA · recruiting
Other recruiting trials for Neuralgia
Currently open trials in the same condition.
- NCT06398847 — Virtual Reality (VR) Self-Hypnosis Software · NA · recruiting
- NCT06796595 — Perioperative Medical Program to Optimize Nerve Regeneration After Robot-assisted Laparoscopic Neurolyses of Pudendal an · recruiting
- NCT05817786 — Treatment of Upper Limb Chronic Neuropathic Pain by Electrical Stimulation of the Brachial Plexus Nerve Roots · NA · recruiting
Other Neurological Associates of West Los Angeles trials
Trials by the same sponsor.
- NCT05970575 — Insulin-sensitizing NE3107 in Improving Sleep and Fatigue in Subjects With Traumatic Brain Injury · Phase 2 · terminated
- NCT04209023 — The Use of Navigated Transcranial Magnetic Stimulation (nTMS) in the Inhibition of Neurofunctional Regions of Interest · NA · suspended
- NCT04770350 — Open Label Study for the Use of Transcranial Ultrasound for Treatment of Age-Related Frailty · EARLY_PHASE1 · unknown
- NCT05041088 — Omega 3 Oil: Aging-Related Cognitive Decline · Phase 1 · unknown
- NCT05475340 — Open Label Study for the Use of Transcranial Ultrasound Treatment of Tremor · EARLY_PHASE1 · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04202783 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Neurological Associates of West Los Angeles
- Last refreshed: 28 September 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04202783.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing