NCT04770350 (fUS-ARF) is a EARLY_PHASE1 clinical trial of Focused Ultrasound in Frailty, sponsored by Neurological Associates of West Los Angeles.

Who is sponsoring NCT04770350?

NCT04770350 is sponsored by Neurological Associates of West Los Angeles.

What drugs are being tested in NCT04770350?

Interventions in NCT04770350: Focused Ultrasound.

What condition does NCT04770350 study?

NCT04770350 studies Frailty, Aging.

Is NCT04770350 still recruiting?

NCT04770350 is currently status unknown. Last updated 28 September 2022.

Last reviewed 2022-09-28 · How we verify

NCT04770350: fUS-ARF

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Open Label Study for the Use of Transcranial Ultrasound for Treatment of Age-Related Frailty

Status unknown EARLY_PHASE1 Last updated 28 September 2022

What this trial tests

EARLY_PHASE1 trial testing Focused Ultrasound in Frailty in 50 participants. Status unknown.

Timeline

1 September 2023

Primary endpoint
30 September 2024

31 December 2024

Quick facts

Lead sponsor	Neurological Associates of West Los Angeles
Phase	EARLY_PHASE1
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	50
Start date	1 September 2023
Primary completion	30 September 2024
Estimated completion	31 December 2024
Sites	1 location across United States

Drugs / interventions tested

Focused Ultrasound

Conditions studied

Frailty — all drugs for Frailty →
Aging — all drugs for Aging →

Sponsor

Neurological Associates of West Los Angeles

Who can join

Adults 45 to 95, any sex, with Frailty or Aging. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this Phase I open label study is to evaluate longer term tolerability and potential effectiveness of transcranial ultrasound in people with age-related frailty.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Current state of clinical ultrasound neuromodulation.
Matt E, Radjenovic S, Mitterwallner M, Beisteiner R. · · 2024 · cited 27× · PMID 38962179 · DOI 10.3389/fnins.2024.1420255

Verify or expand the search:

Other trials of Focused Ultrasound

Trials testing the same drug.

NCT05475340 — Open Label Study for the Use of Transcranial Ultrasound Treatment of Tremor · EARLY_PHASE1 · unknown
NCT05142397 — The Dynamic Process of VMB and Mucosal Immunity After FUS Treatment of CIN Patients With Fertility Requirement · unknown
NCT04852367 — PanDox: Targeted Doxorubicin in Pancreatic Tumours · Phase 1 · withdrawn
NCT04063514 — The Use of Focused Ultrasound and DCE K-trans Imaging to Evaluate Permeability of the Blood-Brain Barrier · NA · enrolling by invitation
NCT04775875 — The Use of Transcranial Ultrasound Treatment of Obsessive-Compulsive Disorder · NA · unknown

Other recruiting trials for Frailty

Currently open trials in the same condition.

NCT07481188 — Frailty and Nottingham Hip Fracture Score for Predicting 90-Day Mortality After Hip Fracture Surgery · recruiting
NCT07519603 — Frailty in Older Adults With Chronic Obstructive Pulmonary Disease (COPD) and Outcomes of the VIVIFRAIL Program · NA · recruiting
NCT07144527 — Nicotinamide Mononucleotide Supplementation for Exercise Tolerance Improvement in Healthy Older Adults · NA · recruiting
NCT07392944 — Multicomponent Exercise Program on Physical Function, Cognition and Falls Risk Among Older Adults Living in Nursing Home · NA · recruiting
NCT07475767 — Ultrasound Indicators of Nutritional Status and Treatment Outcomes in Surgical Patients in the Intensive Care Unit · recruiting

Other Neurological Associates of West Los Angeles trials

Trials by the same sponsor.

NCT05970575 — Insulin-sensitizing NE3107 in Improving Sleep and Fatigue in Subjects With Traumatic Brain Injury · Phase 2 · terminated
NCT04209023 — The Use of Navigated Transcranial Magnetic Stimulation (nTMS) in the Inhibition of Neurofunctional Regions of Interest · NA · suspended
NCT04202783 — The Use of Exosomes In Craniofacial Neuralgia · NA · suspended
NCT05041088 — Omega 3 Oil: Aging-Related Cognitive Decline · Phase 1 · unknown
NCT05475340 — Open Label Study for the Use of Transcranial Ultrasound Treatment of Tremor · EARLY_PHASE1 · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04770350 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Neurological Associates of West Los Angeles
Last refreshed: 28 September 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04770350.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing