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NCT05142397
The Dynamic Process of VMB and Mucosal Immunity After FUS Treatment of CIN Patients With Fertility Requirement
trial testing Focused Ultrasound in Cervical Intraepithelial Neoplasia in 90 participants. Status unknown.
30 June 2023
Quick facts
| Lead sponsor | Shufang Chang |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 90 |
| Start date | 15 August 2021 |
| Primary completion | 30 June 2023 |
| Estimated completion | 30 June 2023 |
| Sites | 1 location across China |
Drugs / interventions tested
- Focused Ultrasound
Conditions studied
- Cervical Intraepithelial Neoplasia — all drugs for Cervical Intraepithelial Neoplasia →
Sponsor
Shufang Chang
Who can join
Adults 18 to 60, female only, with Cervical Intraepithelial Neoplasia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Cervical cancer is the fourth leading cause of cancer death in women worldwide, and cervical intraepithelial neoplasia (CIN) can progress to cervical cancer. Therefore, timely treatment of CIN is critical in preventing the occurrence of cervical cancer. With the implementation and promotion of the World Health Organization's 2030 Global Strategy for the Elimination of Cervical Cancer, an increasing number of women are detecting and treating CIN at an earlier stage. Common treatment methods include ablation treatment and excision treatment, but for women who are planning to have children, the risk of cervical insufficiency and pregnancy complications is greatly increased after excisional treatment, so ablation treatment seems to be a better choice.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Immunomodulation and targeted drug delivery with high intensity focused ultrasound (HIFU): Principles and mechanisms.
Ashar H, Ranjan A. · · 2023 · cited 41× · PMID 36965581 · DOI 10.1016/j.pharmthera.2023.108393
Verify or expand the search:
- PubMed search for NCT05142397
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Focused Ultrasound
Trials testing the same drug.
- NCT04770350 — Open Label Study for the Use of Transcranial Ultrasound for Treatment of Age-Related Frailty · EARLY_PHASE1 · unknown
- NCT05475340 — Open Label Study for the Use of Transcranial Ultrasound Treatment of Tremor · EARLY_PHASE1 · unknown
- NCT04852367 — PanDox: Targeted Doxorubicin in Pancreatic Tumours · Phase 1 · withdrawn
- NCT04063514 — The Use of Focused Ultrasound and DCE K-trans Imaging to Evaluate Permeability of the Blood-Brain Barrier · NA · enrolling by invitation
- NCT04775875 — The Use of Transcranial Ultrasound Treatment of Obsessive-Compulsive Disorder · NA · unknown
Other recruiting trials for Cervical Intraepithelial Neoplasia
Currently open trials in the same condition.
- NCT07275333 — Human Papillomavirus Self-sampling for Enhancing Cervical Screening During the War in Ukraine · NA · recruiting
- NCT06815939 — Validation of a Lab-free Low-cost Screening Test for Prevention of Cervical Cancer · NA · recruiting
- NCT06810427 — A Novel, Low-Cost, Handheld 3D Imaging System for Improved Screening for Cervical Neoplasia in Resource-Limited Settings · NA · active not recruiting
- NCT06191133 — Fenofibrate in Patients With Cervical Intraepithelial Neoplasia and Invasive Cervical Carcinoma · Phase 1 · recruiting
- NCT06243666 — Long-term Effectiveness and Immuno-persistence Study of a Recombinant HPV 16/18 Bivalent Vaccine in Preadolescent Girls · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05142397 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Shufang Chang
- Last refreshed: 18 August 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05142397.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing