NCT07303257: G-SCOPE

Quality of Life After Glaucoma Surgery: Evaluating the Patient Perspective Across Surgical Options - G-SCOPE (Glaucoma Surgery - Comparative Patient Evaluation)

Recruiting now Last updated 12 March 2026

What this trial tests

trial testing NEI-VFQ-25 (National Eye Institute Visual Function Questionnaire-25). in Glaucoma Eye in 132 participants. Currently enrolling.

Timeline

23 February 2026

Primary endpoint
1 August 2027

1 August 2027

Quick facts

Lead sponsor	Hospices Civils de Lyon
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	132
Start date	23 February 2026
Primary completion	1 August 2027
Estimated completion	1 August 2027
Sites	1 location across France

Drugs / interventions tested

• NEI-VFQ-25 (National Eye Institute Visual Function Questionnaire-25).

Conditions studied

• Glaucoma Eye — all drugs for Glaucoma Eye →
• Open-angle Glaucoma — all drugs for Open-angle Glaucoma →
• Closed-Angle Glaucoma — all drugs for Closed-Angle Glaucoma →
• Pseudo Exfoliative Syndrome — all drugs for Pseudo Exfoliative Syndrome →

Sponsor

Hospices Civils de Lyon — full company profile →

Who can join

18 and older, any sex, with Glaucoma Eye or Open-angle Glaucoma. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

• Quality of life score from the NEI-VFQ-25 (National Eye Institute Visual Function Questionnaire-25).
  Time frame: Pre-operative period and 6 months after intervention
  To evaluate, in adult patients undergoing glaucoma surgery, the change in NEI-VFQ 25 quality of life score between the pre-operative period and 6ᵉ months post-operatively, regardless of the surgical technique used.

Sponsor's own description

Glaucoma surgery currently relies on a wide therapeutic arsenal, ranging from conventional filtering surgeries to minimally invasive glaucoma surgery (MIGS). These techniques offer distinct efficacy and safety profiles, allowing tailored management across a broad spectrum of patients. Traditionally, surgical success has been evaluated using objective clinical outcomes, such as intraocular pressure (IOP) reduction and decreased reliance on topical treatments.

However, the shift toward patient-centered medicine now requires consideration of the patient's perspective, including their subjective experience and the impact of treatment on quality of life. In this context, quality-of-life assessment has become a key component, promoting therapeutic alliance and patient adherence to care pathways. Despite its importance, few studies have evaluated and compared quality of life after glaucoma surgery using comparable surgical techniques.

Furthermore, to our knowledge, no study has specifically assessed the independent effect of postoperative follow-up on quality of life after filtering surgery with a bleb. Given that postoperative management can be prolonged and demanding, it may significantly influence patients' perceptions of surgical outcomes and overall well-being.

This study aims to address these gaps by providing a more comprehensive evaluation of the impact of glaucoma surgery beyond traditional clinical outcomes. It may represent a first step toward the development of a more appropriate assessment tool that incorporates the realities of postoperative follow-up and the specific experiences of patients undergoing filtering surgery.

The study is based on the following hypotheses: filtering glaucoma surgery preserves patients' quality of life, with a stable NEI VFQ-25 score at six months postoperatively; postoperative quality of life may be influenced by the patient's postoperative care pathway; and quality-of-life scores remain correlated with objective clinical parameters, including intraocular pressure, visual acuity, medical treatment burden, and visual field damage.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.