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NCT07272668
MA of Tryptophan in Cornmeal in Healthy Adults>60y
NA trial testing Tryptophan in Protein Absorption and Amino Acid Availability in 40 participants. Enrolling by invitation.
1 March 2026
Quick facts
| Lead sponsor | The Hospital for Sick Children |
|---|---|
| Phase | NA |
| Status | ENROLLING BY INVITATION |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 40 |
| Start date | 29 November 2025 |
| Primary completion | 1 March 2026 |
| Estimated completion | 2 May 2026 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Tryptophan (TRYPTOPHAN) — full drug profile →
Conditions studied
- Protein Absorption and Amino Acid Availability — all drugs for Protein Absorption and Amino Acid Availability →
Sponsor
The Hospital for Sick Children
Who can join
Adults 60 to 90, any sex, with Protein Absorption and Amino Acid Availability. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The world's population will reach 12 billion by this century's end. As the human population increases, the world faces the continuous challenge of optimizing a limited food supply. Protein is the key determinant of growth and bodily function. Recently, our group showed that current protein recommendations for adults and children are underestimated by 30-50%. Animal protein production is "more resource intensive than any other form of food production" and their high saturated fat content is linked to chronic diseases in developed nations. Plant protein sources are important alternatives shown to "enhance ecosystem resilience and improve human health". Maize, commonly known as corn, is a staple food in the diets of more than 300 million Africans and ranks as the third most produced food globally. Maize supplies up to 80% of daily energy in sub-Saharan and Southern Africa alone. It is one of the main protein sources in these countries for vegetarians. Already, over 900,000 Canadians adults are vegetarians and globally plant protein consumption is encouraged. However, maize protein is limiting in the essential amino acid (EAA) tryptophan and anti-nutritional factors can affect tryptophan bioavailability (BA). Dietary protein quality (DPQ) depends on its amino acid (AA) composition and BA. Therefore, knowledge of tryptophan BA is fundamental to understand the extent to which cereal grains meet the body's requirement for protein synthesis (PS). Efforts aimed at increasing crop production and DPQ, should coincide with DPQ evaluation directly in humans so that the gap in knowledge between protein requirement and how best to provide it can be quickly and efficiently reconciled.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07272668
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Related trials
Other trials of Tryptophan
Trials testing the same drug.
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- NCT04013555 — The Effects of Kynurenine Aminotransferase Inhibition in People With Schizophrenia · Phase 1, PHASE2 · completed
- NCT02067975 — Tryptophan MRI in People With Schizophrenia and Healthy Controls · Phase 2, PHASE3 · completed
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07272668 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The Hospital for Sick Children
- Last refreshed: 9 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07272668.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing