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NCT06283706
The Tryptophan Requirement in Healthy Adults
NA trial testing Tryptophan in Healthy Aging in 40 participants. Currently enrolling.
1 July 2025
Quick facts
| Lead sponsor | The Hospital for Sick Children |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 40 |
| Start date | 1 June 2024 |
| Primary completion | 1 July 2025 |
| Estimated completion | 1 December 2025 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Tryptophan (TRYPTOPHAN) — full drug profile →
Conditions studied
- Healthy Aging — all drugs for Healthy Aging →
Sponsor
The Hospital for Sick Children
Who can join
Adults 60 to 90, any sex, with Healthy Aging. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aging population is growing rapidly. For the first time ever, Canadian seniors outnumbered young adults in 2016. Aging is associated with many physical and metabolic deteriorations including the loss of muscle mass and strength, insulin resistance, increased inflammation and oxidative stress. The muscles of our bodies are composed of proteins and proteins are made of small building blocks called amino acids. Our bodies have the ability to make some amino acids which are called the non-essential amino acids. However, there are certain amino acids that our body's need to make protein but can only be supplied from the foods that we consume. These are called essential amino acids. Tryptophan is one of the essential amino acids that the body needs. Tryptophan is required for protein synthesis and acts as a precursor for serotonin and nicotinic acid. Therefore, there may be a need for more threonine in the diet of older adults. However, the current requirement for threonine is based on studies conducted exclusively in young adults. Thus, the purpose of this study is to find out how much tryptophan older adults need.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06283706
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Tryptophan
Trials testing the same drug.
- NCT07272668 — MA of Tryptophan in Cornmeal in Healthy Adults>60y · NA · enrolling by invitation
- NCT04013555 — The Effects of Kynurenine Aminotransferase Inhibition in People With Schizophrenia · Phase 1, PHASE2 · completed
- NCT02067975 — Tryptophan MRI in People With Schizophrenia and Healthy Controls · Phase 2, PHASE3 · completed
Other recruiting trials for Healthy Aging
Currently open trials in the same condition.
- NCT07515495 — Effectiveness of Intensive Tutoring vs. Flexible Self-Learning on Digital Health Literacy and Self-Efficacy for "My Heal · NA · recruiting
- NCT07231783 — The Effect of Urolithin A (Mitopure®) Supplementation on Muscle Strength in Healthy Middle-Aged Adults · NA · recruiting
- NCT07308353 — Comparative Effects Of Exergaming And Otago Exercise On Anticipatory Postural Control And Sensory Integration In Older A · NA · active not recruiting
- NCT07207044 — FAXAGE: Fasting And Exercise To Slow Aging In Humans · NA · recruiting
- NCT07151365 — Plant-based Diets and Healthy Aging · recruiting
Other The Hospital for Sick Children trials
Trials by the same sponsor.
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- NCT07508826 — AI-assisted Endotracheal Intubation · NA · not yet recruiting
- NCT07345819 — Dexamethasone vs. Placebo in Children and Youth Hospitalized for Orbital Cellulitis · NA · not yet recruiting
- NCT07497178 — MRgFUS for Childhood Epilepsy · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06283706 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The Hospital for Sick Children
- Last refreshed: 30 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06283706.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing