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L-Tryptophan (TRYPTOPHAN)
L-Tryptophan works by inhibiting the enzyme myeloperoxidase, which is involved in producing reactive oxygen species.
L-Tryptophan is a small molecule tryptophan drug that targets myeloperoxidase. It is not FDA approved for any indications, and its commercial status is unknown. As a tryptophan, it is involved in various biological processes, including protein synthesis and neurotransmitter production. L-Tryptophan's mechanism of action involves inhibiting myeloperoxidase, an enzyme involved in the production of reactive oxygen species. Further information on its clinical use and safety profile is not available.
At a glance
| Generic name | TRYPTOPHAN |
|---|---|
| Drug class | tryptophan |
| Target | Myeloperoxidase, Extracellular calcium-sensing receptor, Probable G-protein coupled receptor 139 |
| Modality | Small molecule |
| Therapeutic area | Other |
| Phase | FDA-approved |
Mechanism of action
CLINIMIX is used as supplement of nutrition in patients, providing macronutrients (amino acids and dextrose) parenterally.The amino acids provide the structural units that make up proteins and are used to synthesize proteins and other biomolecules or are oxidized to urea and carbon dioxide as source of energy.The administered dextrose is oxidized to carbon dioxide and water, yielding energy.
Approved indications
Common side effects
- Metabolic acidosis
- Alkalosis
- Osmotic diuresis and dehydration
- Rebound hypoglycemia
- Hypo- and hyper-vitaminosis
- Pulmonary embolism due to pulmonary vascular precipitates
- Hypersensitivity reactions
- Risk of Infections
- Refeeding syndrome
- Hyperglycemia or hyperosmolar hyperglycemic state
- Vein damage and thrombosis
- Hepatobiliary disorders
Drug interactions
- phenelzine
Key clinical trials
- Isoleucine, Leucine, Valine and Tryptophan Requirements in TPN Fed Neonates (NA)
- Tryptophan Metabolism in Healthy Young Adults (NA)
- Testing the Addition of Darolutamide to Hormonal Therapy (Androgen Deprivation Therapy [ADT]) After Surgery for Men With High-Risk Prostate Cancer, The ERADICATE Study (PHASE3)
- Chronic Subdural Hematoma Embolization With Detachable Coils
- Plant Protein With Ashwagandha-Rhodiola for Sleep Quality (NA)
- Tryptophan as a Modulating Factor in the Antimigraine Efficacy of Triptans
- Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging (PHASE3)
- 5HTP Regulation Of Asthma In Children (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- L-Tryptophan CI brief — competitive landscape report
- L-Tryptophan updates RSS · CI watch RSS