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NCT07266974
To Evaluate Post Operative Pain Using Two Different Kind of Sealers in Obturation of Teeth With Symptomatic Irreversible Pulpitis During Second Visit When the Patient is Painless
Phase 2, PHASE3 trial testing AH-Plus Epoxy Resin Sealer in Post Operative Pain, Acute in 60 participants. Not yet recruiting.
1 September 2026
Quick facts
| Lead sponsor | Jaweria Gul Keyani |
|---|---|
| Phase | Phase 2, PHASE3 |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 1 April 2026 |
| Primary completion | 1 September 2026 |
| Estimated completion | 1 October 2026 |
| Sites | 1 location across Pakistan |
Drugs / interventions tested
- AH-Plus Epoxy Resin Sealer — full drug profile →
- bioceramic sealer — full drug profile →
Conditions studied
- Post Operative Pain, Acute — all drugs for Post Operative Pain, Acute →
- Irreversible Pulpitis — all drugs for Irreversible Pulpitis →
Sponsor
Jaweria Gul Keyani
Who can join
Adults 18 to 40, any sex, with Post Operative Pain, Acute or Irreversible Pulpitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this randomized clinical trial is to evaluate pain after root canal treatment using two different kinds of sealers during obturation in 60 healthy , male and female patients ages between 18 to 40 years. The main aims is to systematically evaluate and compare post-operative pain levels in patients undergoing root canal treatment with two different types of endodontic sealers: AH plus (SEAL APEX) and bio ceramic sealer(META) • By identifying the sealer that leads to the least discomfort, this research could significantly enhance patient care, minimize recovery time, and improve overall treatment success in endodontics. Participants in both groups will be given a visual analogue scale(VAS) to measure the pain level after the root canal treatment has been completed. They will measure pain levels at 12, 24 and 48 hours. All information will be recorded on proforma and compared.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07266974
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of AH-Plus Epoxy Resin Sealer
Trials testing the same drug.
- NCT07246174 — Comparison of AH Plus and WellRootST Root Canal Sealers in Terms of Postoperative Pain: One-Month Follow-up · NA · completed
- NCT06482593 — Periapical Healing in Response to Endodontically Treated Teeth With Different Sealing Cement · Phase 4 · active not recruiting
Other recruiting trials for Post Operative Pain, Acute
Currently open trials in the same condition.
- NCT06982625 — Supra Inguinal Fascia Iliaca Block as Rescue Analgesia Following Total Hip Arthroplasty · NA · recruiting
- NCT07164677 — Serratus Posterior Superior Plane Block for Postoperative Pain in Cardiac Surgery · NA · recruiting
- NCT06741696 — Saline At Different Temperatures After 3rd Molar Surgery · NA · recruiting
- NCT06423859 — Articaine Plus Dexmedetomidine in Supraclavicular Block · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07266974 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Jaweria Gul Keyani
- Last refreshed: 8 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07266974.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing