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bioceramic sealer
Bioceramic sealer is an endodontic filling material that sets through a hydration reaction to create a biocompatible, antimicrobial seal within the root canal system.
Bioceramic sealer is an endodontic filling material that sets through a hydration reaction to create a biocompatible, antimicrobial seal within the root canal system. Used for Root canal obturation and sealing in endodontic therapy.
At a glance
| Generic name | bioceramic sealer |
|---|---|
| Also known as | total fill, endosequence |
| Sponsor | Misr International University |
| Modality | Small molecule |
| Therapeutic area | Dentistry / Endodontics |
| Phase | FDA-approved |
Mechanism of action
Bioceramic sealers are composed of calcium silicates and other bioactive ceramics that undergo hydration when exposed to moisture, forming a hard, mineral-like matrix. This material bonds chemically to dentin, exhibits antimicrobial properties, and promotes periapical healing through bioactivity. The sealer is used in conjunction with gutta-percha or other core materials to obturate the root canal space.
Approved indications
- Root canal obturation and sealing in endodontic therapy
Common side effects
Key clinical trials
- Mineral Trioxide Aggregate (MTA) vs Gutta-Percha for Non-Surgical Endodontic Retreatment in Teeth With Apical Lesions (NA)
- Survival and Success of Two Different Filling Techniques (NA)
- Postoperative Pain After Single-Cone Root Canal Obturation Using Three Sealers (NA)
- Postoperative Pain After Root Canal Obturation Using Bioceramic and Calcium Hydroxide Sealers (NA)
- Comparative Evaluation of Post Obturation Pain After Root Canal Treatment Using Tricalcium Silicate vs Resin-Based Sealers (NA)
- The Effect of Sealer Type and Obturation Technique on Postoperative Pain (NA)
- Vital Pulp Therapy vs. Root Canal Treatment in Mature Teeth With Irreversible Pulpitis (NA)
- To Evaluate Post Operative Pain Using Two Different Kind of Sealers in Obturation of Teeth With Symptomatic Irreversible Pulpitis During Second Visit When the Patient is Painless (PHASE2, PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- bioceramic sealer CI brief — competitive landscape report
- bioceramic sealer updates RSS · CI watch RSS
- Misr International University portfolio CI