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NCT07434141: POP-RCT
Comparative Analysis of Postoperative Pain in Symptomatic Irreversible Pulpitis Teeth Following Single Cone Obturation Using Three Different Sealers: A Randomized Clinical Trial
NA trial testing Endoseal TCS in Symptomatic Irreversible Pulpitis (SIP) in 75 participants. Participants enrolled and being followed up; not accepting new ones.
1 April 2026
Quick facts
| Lead sponsor | Tehran University of Medical Sciences |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 75 |
| Start date | 8 June 2025 |
| Primary completion | 1 April 2026 |
| Estimated completion | 30 May 2026 |
| Sites | 1 location across Iran |
Drugs / interventions tested
- Endoseal TCS
- Neosealer
- AH Plus
Conditions studied
- Symptomatic Irreversible Pulpitis (SIP) — all drugs for Symptomatic Irreversible Pulpitis (SIP) →
- Symptomatic Irreversible Pulpitis With Apical Peridontitis — all drugs for Symptomatic Irreversible Pulpitis With Apical Peridontitis →
Sponsor
Tehran University of Medical Sciences
Who can join
Adults 18 to 60, any sex, with Symptomatic Irreversible Pulpitis (SIP) or Symptomatic Irreversible Pulpitis With Apical Peridontitis. Healthy volunteers can join.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Post-Endodontic Pain Intensity
Time frame: Pain will be assessed at 6, 12,18, 24, and 48 hours post-treatment
Pain intensity experienced by participants after root canal treatment will be measured using a Visual Analog Scale (VAS; 0-10 numeric rating scale), where: 0 = no pain 10 = worst imaginable pain Higher scores indicate greater pain intensity (worse outcome). Participants will also record the number of analgesic tablets consumed during the first 48 hours after treatment. The maximum VAS pain sc
Sponsor's own description
The goal of this clinical trial is to compare post-treatment pain after root canal therapy in adults with irreversible pulpitis using different root canal sealers. The study will also evaluate the need for pain medication after treatment. The main questions this study aims to answer are: Does the type of root canal sealer affect the intensity of pain after treatment? Does the type of sealer influence the number of analgesic tablets taken by participants? How does pain change over time after treatment with different sealers? Researchers will compare two bioceramic sealers (EndoSeal TCS and NeoSeal) with a resin-based sealer (AH Plus) to determine their effects on post-endodontic pain. Participants will: Receive root canal treatment using one of the study sealers Report their pain intensity at specific time points after treatment Record the number of analgesic tablets taken during the follow-up period
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07434141
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Symptomatic Irreversible Pulpitis (SIP)
Currently open trials in the same condition.
- NCT07517367 — Intraoral Cryotherapy on Anesthetic Efficacy in Mandibular Incisors · Phase 4 · recruiting
- NCT07239505 — A Randomized Controlled Trial Evaluating Whether Pre-operative Trinase Reduces Post-operative Pain in Patients With Symp · NA · recruiting
- NCT07290049 — Postoperative Pain After Pulpotomy in Children Using Calcium Silicate Cements With and Without Laser Therapy · NA · recruiting
- NCT06880471 — Postoperative Pain After Full Pulpotomy With TheraCal PT, Biodentin, and MTA · NA · recruiting
- NCT07483788 — Short Term Comparative Assessment of MTA and Biodentine in Complete Pulpotomy for Symptomatic Irreversible Pulpitis · NA · recruiting
Other Tehran University of Medical Sciences trials
Trials by the same sponsor.
- NCT07305883 — Comparison of Intranasal Ketorolac and Intranasal Ketamine in Digital Nerve Block Pain · Phase 3 · not yet recruiting
- NCT06876194 — The Effect of Music on the Sedation Quality Among Children in the Emergency Department. · Phase 3 · completed
- NCT06721273 — Iodine Supplementation and Fertility Parameters · NA · not yet recruiting
- NCT07014397 — Effect of Valaciclovir on Inter-Appointment Pain in Endodontic Treatment of Necrotic Teeth · NA · completed
- NCT06615934 — Effects of Aerobic and Resistance Exercises on Inpatients Liver Transplantation Recipients · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07434141 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Tehran University of Medical Sciences
- Last refreshed: 21 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07434141.
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