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NCT07517367
Intraoral Cryotherapy on Anesthetic Efficacy in Mandibular Incisors
Phase 4 trial testing Cryotherapy in Symptomatic Irreversible Pulpitis (SIP) in 98 participants. Currently enrolling.
1 August 2026
Quick facts
| Lead sponsor | Ondokuz Mayıs University |
|---|---|
| Phase | Phase 4 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 98 |
| Start date | 31 December 2025 |
| Primary completion | 1 August 2026 |
| Estimated completion | 30 August 2026 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Cryotherapy (CRYOTHERAPY) — full drug profile →
Conditions studied
- Symptomatic Irreversible Pulpitis (SIP) — all drugs for Symptomatic Irreversible Pulpitis (SIP) →
Sponsor
Ondokuz Mayıs University
Who can join
Adults 18 to 60, any sex, with Symptomatic Irreversible Pulpitis (SIP). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim is to compare the contributions of intraoral cryotherapy and supplemental lingual infiltration anesthesia to buccal infiltration anesthesia in mandibular incisor teeth with irreversible pulpitis in terms of anesthetic efficacy, and to evaluate the effect of adding intraoral cryotherapy to buccal anesthesia on anesthetic efficacy.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07517367
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Cryotherapy
Trials testing the same drug.
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- NCT07366736 — Monocentric Randomised Controlled Trial Assessing Cryocompression Following Total Knee Replacement · NA · recruiting
- NCT07211412 — Acute Cryotherapy on Musculoskeletal Function and Biomarkers · NA · not yet recruiting
- NCT06921200 — Effect of Perineal Cryotherapy on Episiotomy · NA · not yet recruiting
Other recruiting trials for Symptomatic Irreversible Pulpitis (SIP)
Currently open trials in the same condition.
- NCT07239505 — A Randomized Controlled Trial Evaluating Whether Pre-operative Trinase Reduces Post-operative Pain in Patients With Symp · NA · recruiting
- NCT07290049 — Postoperative Pain After Pulpotomy in Children Using Calcium Silicate Cements With and Without Laser Therapy · NA · recruiting
- NCT06880471 — Postoperative Pain After Full Pulpotomy With TheraCal PT, Biodentin, and MTA · NA · recruiting
- NCT07483788 — Short Term Comparative Assessment of MTA and Biodentine in Complete Pulpotomy for Symptomatic Irreversible Pulpitis · NA · recruiting
Other Ondokuz Mayıs University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07517367 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ondokuz Mayıs University
- Last refreshed: 8 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07517367.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing