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AH-Plus Epoxy Resin Sealer
AH-Plus is an epoxy resin-based root canal sealer that polymerizes and forms a tight seal within the root canal system to prevent bacterial leakage and promote healing.
AH-Plus is an epoxy resin-based root canal sealer that polymerizes and forms a tight seal within the root canal system to prevent bacterial leakage and promote healing. Used for Root canal obturation and sealing in endodontic therapy.
At a glance
| Generic name | AH-Plus Epoxy Resin Sealer |
|---|---|
| Sponsor | Institucion Universitaria Colegios de Colombia |
| Drug class | Epoxy resin root canal sealer |
| Modality | Small molecule |
| Therapeutic area | Dentistry/Endodontics |
| Phase | FDA-approved |
Mechanism of action
AH-Plus sets through an acid-base reaction between epoxy resin and hexamethylenetetramine, creating a dimensionally stable polymer that bonds to dentin and gutta-percha. It releases formaldehyde during setting, which contributes to antimicrobial properties. The sealer is radiopaque and biocompatible, designed to create an impermeable barrier that prevents reinfection of endodontically treated teeth.
Approved indications
- Root canal obturation and sealing in endodontic therapy
Common side effects
- Allergic sensitization (rare)
- Periapical inflammation if extruded
- Cytotoxicity to periapical tissues (minimal with proper placement)
Key clinical trials
- Survival and Success of Two Different Filling Techniques (NA)
- Postoperative Pain After Single-Cone Root Canal Obturation Using Three Sealers (NA)
- Comparative Evaluation of Post Obturation Pain After Root Canal Treatment Using Tricalcium Silicate vs Resin-Based Sealers (NA)
- Sealers in Chronic Apical Lesions (NA)
- To Evaluate Post Operative Pain Using Two Different Kind of Sealers in Obturation of Teeth With Symptomatic Irreversible Pulpitis During Second Visit When the Patient is Painless (PHASE2, PHASE3)
- Evaluation of Postoperative Pain After Using Resin-Based and Bioceramic Sealers in Mandibular Molars With Asymptomatic Apical Periodontitis (NA)
- Comparison of Post Operative Pain in Resin-Based and Bioceramic Based Root Canal Sealers in Patient Presenting at Peshawar Dental College. (NA)
- Comparison of AH Plus and WellRootST Root Canal Sealers in Terms of Postoperative Pain: One-Month Follow-up (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- AH-Plus Epoxy Resin Sealer CI brief — competitive landscape report
- AH-Plus Epoxy Resin Sealer updates RSS · CI watch RSS
- Institucion Universitaria Colegios de Colombia portfolio CI