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NCT07102641: PACESS
PACESS: Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies
Phase 4 trial testing Acetaminophen in Cesarean Delivery in 825 participants. Currently enrolling.
1 August 2027
Quick facts
| Lead sponsor | Thomas Jefferson University |
|---|---|
| Phase | Phase 4 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 825 |
| Start date | 26 August 2025 |
| Primary completion | 1 August 2027 |
| Estimated completion | 1 December 2027 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Acetaminophen (Paracetamol) — full drug profile →
- NSAID (Ketorolac/Ibuprofen) — full drug profile →
Conditions studied
- Cesarean Delivery — all drugs for Cesarean Delivery →
- Postpartum Comfort — all drugs for Postpartum Comfort →
- Postpartum Pain — all drugs for Postpartum Pain →
- Post-operative Pain — all drugs for Post-operative Pain →
Sponsor
Thomas Jefferson University
Who can join
16 and older, female only, with Cesarean Delivery or Postpartum Comfort. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Postpartum pain control
Time frame: 48 (+/- 2) hours postpartum
Visual analog pain score (VAS) with movement. Scale ranges from 0-10 with 0 indicating no pain and 10 indicating worst possible pain -
Opioid consumption
Time frame: Postpartum Admission (From time of surgery to hospital discharge; typically 2-5 days)
Opioid consumption (in total morphine milligram equivalents (MME))
Sponsor's own description
Cesarean delivery is a commonly performed surgical procedure associated with worse postpartum pain when compared to vaginal birth. Uncontrolled postpartum pain is associated with increased neonatal and maternal risks. Multimodal non-opioid pain medications, including acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) are the preferred first-line therapies. There is no standard practice, however, on best dosing schedules (ie staggered or different time v. simultaneous or same time). This protocol describes a randomized clinical trial aimed to determine whether staggered dosing of acetaminophen and NSAIDs in superior to simultaneous dosing in controlling post-cesarean pain.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07102641
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Currently open trials in the same condition.
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Other Thomas Jefferson University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07102641 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Thomas Jefferson University
- Last refreshed: 2 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07102641.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing