Last reviewed · How we verify
NCT07098494
Probiotics and Post-Pullthrough Hirschsprung's Disease-Associated Enterocolitis
NA trial testing Saccharomyces Boulardii Probiotic Supplement in Hirschsprung Disease in 88 participants. Completed in 30 September 2024.
29 September 2024
Quick facts
| Lead sponsor | Aswan University Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 88 |
| Start date | 1 January 2018 |
| Primary completion | 29 September 2024 |
| Estimated completion | 30 September 2024 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Saccharomyces Boulardii Probiotic Supplement — full drug profile →
Conditions studied
- Hirschsprung Disease — all drugs for Hirschsprung Disease →
- Enterocolitis — all drugs for Enterocolitis →
- Hirschsprung's Disease Associated Enterocolitis — all drugs for Hirschsprung's Disease Associated Enterocolitis →
Sponsor
Aswan University Hospital
Who can join
Adults 2 Months to 12, any sex, with Hirschsprung Disease or Enterocolitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This was a prospective case-controlled study investigating the role of probiotics in the management of Hirschsprung-associated enterocolitis (HAEC). The study was conducted across three children's hospitals in Upper Egypt, spanning from January 2018 to September 2024. The study was randomized, with parents of the participating children choosing one of two paper forms to become either included in the probiotic treatment regimen or adhere to the standard treatment protocol without probiotics, the latter serving as the control group. The inclusion criteria encompassed children under 12 years of age and admitted for treatment of a grade II post-pullthrough HAEC episode. Exclusion criteria included patients with severe comorbidities, hemodynamic instability, active septicemia, grade III HAEC, other congenital anomalies, trisomy 21, inability to tolerate or take oral probiotics, probiotic sensitivities, or any contraindications to probiotic use.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07098494
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Saccharomyces Boulardii Probiotic Supplement
Trials testing the same drug.
- NCT05231772 — Probiotics and Hemodynamic Changes in Cirrhosis · NA · completed
Other recruiting trials for Hirschsprung Disease
Currently open trials in the same condition.
- NCT06573723 — Institutional Registry of Rare Diseases · recruiting
- NCT06590142 — Hirschsprung's Advances; Working Towards Autologous tIssue therapIes · recruiting
- NCT06650683 — Impact of Providing Nursing Support on Parental Stress Related to Preoperative Care of a Newborn with Hirschsprung's Dis · NA · recruiting
- NCT05450991 — Long-term Qualitative and Quantitative Outcomes of Children With Hirschsprung's Disease and Anorectal Malformations · recruiting
- NCT07519915 — Improvement of Understanding of Pediatric Sacral Neuromodulation: Therapeutic Strategies and Outcome Variables · NA · recruiting
Other Aswan University Hospital trials
Trials by the same sponsor.
- NCT06491394 — Lactoferrin Effect on Kidney and Heart of Rhabdomyolysis Rats · Phase 4 · completed
- NCT06583590 — Evaluation of Efficacy of Botulinum Toxin A Plus Oral Tadalafil 5 mg in Diabetic Men With Erectile Dysfunction · Phase 2, PHASE3 · recruiting
- NCT06211088 — Famotidine Versus Placebo in Emergency Pediatric Surgery As a Risk to Postoperative Nausea and Vomiting · NA · completed
- NCT06535256 — Compare Intraperitoneal Instillation of Bupivacaine+dexmedetomidine Versus Bupivacaine+dexamethasone on Postoperative Pa · NA · completed
- NCT06537323 — Femoral Nerve Block, Periarticular Nerve Group (PENG) Block, and Preoperative IV Fentanyl · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07098494 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Aswan University Hospital
- Last refreshed: 1 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07098494.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing