Last reviewed · How we verify
NCT06590142: HAWAII
Hirschsprung's Advances; Working Towards Autologous tIssue therapIes
trial testing Observational study of tissue specimens in Hirschsprung Disease in 300 participants. Currently enrolling.
1 March 2034
Quick facts
| Lead sponsor | Alder Hey Children's NHS Foundation Trust |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 300 |
| Start date | 5 March 2024 |
| Primary completion | 1 March 2034 |
| Estimated completion | 1 March 2036 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Observational study of tissue specimens
Conditions studied
- Hirschsprung Disease — all drugs for Hirschsprung Disease →
Sponsor
Alder Hey Children's NHS Foundation Trust
Who can join
Adults 0 to 15, any sex, with Hirschsprung Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Children with Hirschsprung's Disease (HSCR) have no normal nerve cells in the lower end of their bowel. This can cause babies to die if left untreated treated. Currently the part of bowel that doesn't have normal nerves is removed with an operation, but this can have long-term complications including needing a permanent bag on the tummy for poo (stoma). Because of this there is an urgent need for better treatments. The investigators have found that children with HSCR have nerve stem cells throughout their bowel, even in the lower end where the nerves haven't grown normally. We can grow these stem cells in the laboratory to form balls of nerve cells (neurospheres). The investigators want to find out whether these neurospheres grow into the nerves that are needed for the bowel to work normally. First the investigators will see how the nerve stem cells from the lower end of the bowel grow compared to those from the normal bowel. Then the investigators will see if the neurospheres change when the investigators put them with medications that affect growth of bowel nerves. At the end of this project the investigators hope to know whether the nerve stem cells at the lower part of the bowel in children with HSCR can turn into bowel nerve cells that might make the bowel work normally. The investigators also hope to know whether the investigators can use medications to make the stem cells turn into normal nerves, meaning that children with HSCR could avoid an operation and a stoma.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06590142
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Hirschsprung Disease
Currently open trials in the same condition.
- NCT06573723 — Institutional Registry of Rare Diseases · recruiting
- NCT06650683 — Impact of Providing Nursing Support on Parental Stress Related to Preoperative Care of a Newborn with Hirschsprung's Dis · NA · recruiting
- NCT05450991 — Long-term Qualitative and Quantitative Outcomes of Children With Hirschsprung's Disease and Anorectal Malformations · recruiting
- NCT07519915 — Improvement of Understanding of Pediatric Sacral Neuromodulation: Therapeutic Strategies and Outcome Variables · NA · recruiting
- NCT04622410 — Registry for Hirschsprung Disease of the BELAPS · recruiting
Other Alder Hey Children's NHS Foundation Trust trials
Trials by the same sponsor.
- NCT05469711 — PlayPhysio: Making Physio Fun · NA · completed
- NCT05450991 — Long-term Qualitative and Quantitative Outcomes of Children With Hirschsprung's Disease and Anorectal Malformations · recruiting
- NCT05614427 — The LAVA (Lateral Flow Antigen Validation and Applicability) 2 Study for COVID-19 · NA · completed
- NCT04629157 — The LAVA (Lateral Flow Antigen Validation and Applicability) Study for COVID-19 · NA · completed
- NCT03047876 — Brain Vascular Reactivity to Hypothermic Circulatory Arrest With Antegrade Cerebral Perfusion During Aortic Arch Surgery · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06590142 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Alder Hey Children's NHS Foundation Trust
- Last refreshed: 19 September 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06590142.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing