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NCT06971770
EVALUATION OF SALIVARY BİOMARKER LEVELS IN SMOKING AND NON-SMOKER INDIVIDUALS WITH DIFFERENT PERIODONTAL DISEASES
NA trial testing saliva obtaining in Periodontal Diseases in 80 participants. Completed in 1 February 2025.
1 November 2024
Quick facts
| Lead sponsor | Izmir Katip Celebi University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 80 |
| Start date | 1 April 2024 |
| Primary completion | 1 November 2024 |
| Estimated completion | 1 February 2025 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- saliva obtaining
Conditions studied
- Periodontal Diseases — all drugs for Periodontal Diseases →
Sponsor
Izmir Katip Celebi University
Who can join
Adults 18 to 70, any sex, with Periodontal Diseases. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study aimed to compare various cytokine levels in saliva samples in order to understand the pathogenesis of chronic inflammatory diseases. In particular, HMGB1, sTREM-1 and TNF-α levels were examined between smokers and non-smokers with periodontitis and non-smokers with gingivitis and periodontally healthy individuals. 80 systemically healthy individuals were included in the study. These individuals were divided into four groups: 20 non-smoker periodontally healthy, 20 non-smoker with gingivitis, 20 non- smokers with periodontitis and 20 smokers with periodontitis. Periodontal clinical parameters of each individual were measured and saliva samples were taken. HMGB1, sTREM-1 and TNF-α levels in the saliva samples were determined by enzyme-linked immunoassay (ELISA) method. Statistical analyses were performed on the data to examine the differences in cytokine levels between the groups and the relationships of these cytokines with clinical parameters. The findings obtained may contribute to the research of potential biomarkers that can be used in the diagnosis of periodontal diseases and new ways of treatment processes.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06971770
- Europe PMC full search
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Related trials
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Other recruiting trials for Periodontal Diseases
Currently open trials in the same condition.
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Other Izmir Katip Celebi University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06971770 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Izmir Katip Celebi University
- Last refreshed: 14 May 2025
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