NCT06848790: HIJA

Interdental Hygiene Methods in Young Adults

Recruiting now NA Last updated 19 November 2025

What this trial tests

NA trial testing Calibrated interdental brush in Microbiota-related Disease in 55 participants. Currently enrolling.

Timeline

17 September 2025

Primary endpoint
3 March 2026

17 June 2026

Quick facts

Lead sponsor	Hospices Civils de Lyon
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	55
Start date	17 September 2025
Primary completion	3 March 2026
Estimated completion	17 June 2026
Sites	1 location across France

Drugs / interventions tested

• Calibrated interdental brush

Conditions studied

• Microbiota-related Disease — all drugs for Microbiota-related Disease →
• Oral Hygiene — all drugs for Oral Hygiene →
• Periodontal Diseases — all drugs for Periodontal Diseases →

Sponsor

Hospices Civils de Lyon — full company profile →

Who can join

18 and older, any sex, with Microbiota-related Disease or Oral Hygiene. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Oral health is essential for overall well-being and systemic health. A key factor in preserving this health is maintaining the balance of the interdental microbiota, which involves regulating the quantity of pathogenic bacteria in interdental spaces (IS). These IS represent a unique ecological niche where the body has limited specific defense mechanisms, making them vulnerable to infections.

In adults, the colonization of interdental spaces by pathogenic bacteria increases the risk of periodontal diseases, which are themselves associated with non-communicable diseases such as cardiovascular diseases, diabetes, and certain types of cancer.

Preventing interdental microbiota dysbiosis from a young age is therefore a priority to maintain quality oral health and contribute to good systemic health throughout life. However, conventional brushing techniques cover only accessible tooth surfaces and cannot reach the interdental spaces. Currently, the use of interdental brushes (IDBs) is recognized as the most effective method for interdental hygiene. There are various types of IDBs, differing in several aspects that influence their effectiveness and usability. The main differences relate to their shape, size, and calibration using an interdental probe or not, allowing adaptation to different interdental space sizes. To date, only one study has demonstrated the effectiveness of daily calibrated interdental brush use in reducing dysbiosis and interdental inflammation among young adults. However, no research has yet been conducted to compare the effectiveness of the various types of IDBs available on the market (calibrated versus non-calibrated).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Effectiveness of Different Methods of Interdental Hygiene in Daily Practice Among Young Adults: Protocol for a Randomized, Single-Blind Controlled Trial.
   Carrouel F, Lan R, Saliasi I, Bourgeois D, et al · · 2025 · PMID 41343847 · DOI 10.2196/85154