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NCT06713512: ESSENTIAL
InvEstigating oeStrogen Signalling and the Effect upoN the exTracelluar Matrix In pAtients With Obstructive Lung Disease
trial testing No intervention in Chronic Obstructive Lung Disease in 100 participants. Currently enrolling.
1 January 2026
Quick facts
| Lead sponsor | Guy's and St Thomas' NHS Foundation Trust |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 100 |
| Start date | 1 December 2024 |
| Primary completion | 1 January 2026 |
| Estimated completion | 1 November 2028 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- No intervention
Conditions studied
- Chronic Obstructive Lung Disease — all drugs for Chronic Obstructive Lung Disease →
- Respiratory Ilness — all drugs for Respiratory Ilness →
- Estrogen Deficiency — all drugs for Estrogen Deficiency →
- Asthma — all drugs for Asthma →
Sponsor
Guy's and St Thomas' NHS Foundation Trust
Who can join
Adults 18 to 99, any sex, with Chronic Obstructive Lung Disease or Respiratory Ilness. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study aims to understand the role of oestrogen in patients with asthma and Chronic Obstructive Pulmonary Disorder (COPD). Therefore, what is the effect of oestrogen in these participants compared to controls (those without disease). The study hypothesises that oestrogen loss in patients with asthma and COPD causes accelerated lung function decline and changes to lung structure. It will investigate if this is mediated by inflammation, immune host response or elastin and collagen changes. It is an observational prospective cohort study aiming to recruit healthy controls, and people with asthma or COPD), and/or the menopause.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06713512
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Currently open trials in the same condition.
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Other Guy's and St Thomas' NHS Foundation Trust trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06713512 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Guy's and St Thomas' NHS Foundation Trust
- Last refreshed: 3 December 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06713512.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing