Last reviewed · How we verify
NCT07534917: LvL-PACE
Comparing the Effects of Newer Pacemakers and Their Effects on the Heart and Valve Function in the Short-term.
trial testing Temporary left bundle branch area pacing in Pacemaker-Induced Cardiomyopathy in 20 participants. Not yet recruiting.
30 January 2029
Quick facts
| Lead sponsor | Guy's and St Thomas' NHS Foundation Trust |
|---|---|
| Status | Not yet recruiting |
| Study type | OBSERVATIONAL |
| Enrollment | 20 |
| Start date | 1 June 2026 |
| Primary completion | 30 January 2029 |
| Estimated completion | 1 June 2029 |
Drugs / interventions tested
- Temporary left bundle branch area pacing
- Temporary leadless right ventricular pacing
Conditions studied
- Pacemaker-Induced Cardiomyopathy — all drugs for Pacemaker-Induced Cardiomyopathy →
- Tricuspid Regurgitation — all drugs for Tricuspid Regurgitation →
- Right Ventricular Dysfunction — all drugs for Right Ventricular Dysfunction →
Sponsor
Guy's and St Thomas' NHS Foundation Trust
Who can join
18 and older, any sex, with Pacemaker-Induced Cardiomyopathy or Tricuspid Regurgitation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Conventional pacemakers involve placing a lead through a valve into the bottom right chamber of the heart. Research has shown that this is associated with an increased risk of valve dysfunction and mortality as well as impairment of heart function.Newer pacemakers such as leadless pacemakers and pacemakers that engage directly with the heart's native conduction system (known as left bundle branch pacemakers), are increasingly being adopted. However, the impact of these newer pacing technologies on the heart and tricuspid valve, as well as how they compare against each other, is unclear. We aim to study the impact of leadless pacemakers and left bundle branch pacemakers on cardiac function and tricuspid valve by conducting an acute study that will be performed in addition to the routine pacemaker implantation that the participant has been referred for. Both procedures will be performed in one sitting under general anaesthesia. Outcomes from this study will improve our understanding of how these pacing technologies affect heart and valve function and how they compare against each other. This will guide decision-making regarding the ideal type of pacemaker to be adopted, especially in patients who stand to suffer the most from developing tricuspid valve or heart dysfunction.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07534917
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Pacemaker-Induced Cardiomyopathy
Currently open trials in the same condition.
- NCT05910866 — LEft Bundle branchArea Pacing to Avoid Pacing-induced CARdiomyopathy · NA · recruiting
- NCT05541679 — Comparison of Left Bundle Branch Area Versus Right Ventricular Septal Pacing in Patients With High-degree Conduction Dis · NA · active not recruiting
Other Guy's and St Thomas' NHS Foundation Trust trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07534917 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Guy's and St Thomas' NHS Foundation Trust
- Last refreshed: 16 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07534917.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing