Last reviewed · How we verify
NCT06632080
Effects of Substance P on Headache Induction in Healthy Individuals
NA trial testing Substance P in Healthy Volunteers Only in 21 participants. Not yet recruiting.
31 December 2025
Quick facts
| Lead sponsor | Danish Headache Center |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | quadruple |
| Primary purpose | basic science |
| Enrollment | 21 |
| Start date | 14 October 2024 |
| Primary completion | 31 December 2025 |
| Estimated completion | 31 December 2025 |
| Sites | 1 location across Denmark |
Drugs / interventions tested
- Substance P — full drug profile →
- Placebo
Conditions studied
- Healthy Volunteers Only — all drugs for Healthy Volunteers Only →
Sponsor
Danish Headache Center — full company profile →
Who can join
Adults 18 to 65, any sex, with Healthy Volunteers Only. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Substance P is a signaling molecule that has been implicated in the pathogenesis of headache. This study aims to ascertain whether administration of substance P can induce headache in healthy adults.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effects of substance P on headache induction and arterial dilation in healthy adults.
Al-Khazali HM, Christensen RH, Gozalov E, Hakimzadeh Z, et al · · 2025 · cited 8× · PMID 40369974 · DOI 10.1177/03331024251336132
Verify or expand the search:
- PubMed search for NCT06632080
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Substance P
Trials testing the same drug.
- NCT06959004 — Substance P-Induced Migraine Attacks Without Aura · NA · recruiting
- NCT04676763 — Substance P Challenge in Healthy Participants · NA · completed
- NCT03738878 — Mechanism(s) Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 1 · Phase 4 · terminated
Other recruiting trials for Healthy Volunteers Only
Currently open trials in the same condition.
- NCT06917482 — A Study to Assess the Safety and Effects of the Investigational Drug BW-40202 in Healthy Volunteers · Phase 1 · recruiting
Other Danish Headache Center trials
Trials by the same sponsor.
- NCT07451769 — Selective Activation of the Adrenomedullin Receptors in Migraine · NA · not yet recruiting
- NCT07342296 — Induction of Migraine Attacks With Aura Using Pituitary Adenylate Cyclase Activating Polypeptide-38 · NA · not yet recruiting
- NCT07059546 — Hypersensitivity to Adrenomedullin in Post-Traumatic Headache · NA · recruiting
- NCT07021859 — Induction of Migraine Attacks With Aura Using Calcitonin Gene-Related Peptide · NA · recruiting
- NCT06959004 — Substance P-Induced Migraine Attacks Without Aura · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06632080 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Danish Headache Center
- Last refreshed: 15 October 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06632080.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing