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NCT06614881
Dexmedetomidine Dosage for Postoperative Delirium and Cognitive Function in Elderly TKA Patients
NA trial testing Dexmedetomidine Injection [Precedex] in Post Operative Delirium in 132 participants. Completed in 1 November 2024.
15 October 2024
Quick facts
| Lead sponsor | Tanta University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 132 |
| Start date | 1 July 2024 |
| Primary completion | 15 October 2024 |
| Estimated completion | 1 November 2024 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Dexmedetomidine Injection [Precedex] — full drug profile →
- Dexmedetomidine in 0.9 % NaCl 1,000 Mcg/250 mL (4 Mcg/mL) INTRAVEN INFUSION BOTTLE (ML) — full drug profile →
- Dexmedetomidine in 0.9 % NaCl 1,000 Mcg/250 mL (4 Mcg/mL) INTRAVEN INFUSION BOTTLE (ML) — full drug profile →
- Dexmedetomidine in 0.9 % NaCl 1,000 Mcg/250 mL (4 Mcg/mL) INTRAVEN INFUSION BOTTLE (ML) — full drug profile →
- Normal saline
Conditions studied
- Post Operative Delirium — all drugs for Post Operative Delirium →
Sponsor
Tanta University
Who can join
Adults 35 to 65, any sex, with Post Operative Delirium. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study aims to evaluate the efficacy of dexmedetomidine in reducing the incidence of postoperative delirium and cognitive dysfunction in elderly patients undergoing total knee arthroplasty (TKA). The study will compare the outcomes of patients receiving dexmedetomidine to those receiving a standard anesthetic or sedative, focusing on factors such as patient characteristics, surgical duration, and postoperative care. The research will explore the potential neuroprotective effects of dexmedetomidine and its ability to mitigate the risks associated with anesthesia and surgery in vulnerable elderly populations.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06614881
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Dexmedetomidine Injection [Precedex]
Trials testing the same drug.
- NCT06867302 — Dexmedetomidine and Agitation After Nasal Surgery · NA · recruiting
- NCT06386770 — Systemic Versus Local Dexmedetomidine as An Adjuvant to Bupivacaine in Ultrasound Guided Erector Spinae Block · Phase 3 · recruiting
- NCT07434206 — Safety and Efficacy of Dexmedetomidine in Controlling Hemodynamics During Resection of Active Thyroid Secreting Tumors · Phase 2, PHASE3 · active not recruiting
- NCT05788393 — Opioid Sparing Analgesia Continuous Intraoperative Infusion of Dexmedetomidine Versus Lidocaine for Laparoscopic Cholecy · Phase 4 · completed
- NCT06090955 — Modulating Surgery-Induced Blood-Brain Barrier Disruption in Elderly · NA · recruiting
Other recruiting trials for Post Operative Delirium
Currently open trials in the same condition.
- NCT06613178 — Intravenous Acetaminophen After Cardiac Surgery - Definitive Study · Phase 4 · recruiting
- NCT06355570 — Delirium After Cardiac Surgery in Intensive Care Units · NA · recruiting
- NCT05242419 — A Study of Huperzine A Injection in Reducing Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery · NA · recruiting
- NCT05765162 — Safe Brain Initiative, Operationalizing Precision Anaesthesia · recruiting
Other Tanta University trials
Trials by the same sponsor.
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- NCT07334197 — Effect of Melatonin on Left Ventricular Reverse Remodeling and Inflammation in Peripartum Cardiomyopathy · NA · not yet recruiting
- NCT07498998 — Glucocorticoid, Ozone and 5% Dextrose Local Injection for Pain Relief in Carpal Tunnel Syndrome · NA · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06614881 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Tanta University
- Last refreshed: 26 November 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06614881.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing