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NCT06966856
This Randomized, Clinical Trial Evaluates the Efficacy of Oral Versus Sublingual Vitamin B12 Supplementation in Correcting Early-onset Vitamin B12 Deficiency in Adult Patients Using Proton Pump Inhibitors (PPIs). The Primary Outcome is the Change in Serum Vitamin B12 Levels Over a 6-week
Phase 3 trial testing Cyanocobalamin 1000 Mcg Oral Tablet in Hypovitaminosis b 12 in 23 participants. Not yet recruiting.
30 December 2028
Quick facts
| Lead sponsor | Tanta University |
|---|---|
| Phase | Phase 3 |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 23 |
| Start date | 30 December 2026 |
| Primary completion | 30 December 2028 |
| Estimated completion | 30 December 2029 |
Drugs / interventions tested
- Cyanocobalamin 1000 Mcg Oral Tablet — full drug profile →
- Cyanocobalamin 1000 Mcg Sublingual Tablet — full drug profile →
- Proton Pump Inhibitor therapy only
Conditions studied
- Hypovitaminosis b 12 — all drugs for Hypovitaminosis b 12 →
Sponsor
Tanta University
Who can join
18 and older, any sex, with Hypovitaminosis b 12. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This randomized, clinical trial evaluates the efficacy of oral versus sublingual vitamin B12 supplementation in correcting early-onset vitamin B12 deficiency in adult patients using proton pump inhibitors (PPIs). The primary outcome is the change in serum vitamin B12 levels over a 6-week treatment period. Secondary outcomes include changes in homocysteine levels, hemoglobin levels, and patient-reported satisfaction.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06966856
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06966856 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Tanta University
- Last refreshed: 13 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06966856.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing