Last reviewed · How we verify
NCT06376734: Expedition
Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness
Phase 2 trial testing Transcranial magnetic stimulation in Major Depressive Disorder in 180 participants. Currently enrolling.
1 June 2029
Quick facts
| Lead sponsor | Brigham and Women's Hospital |
|---|---|
| Phase | Phase 2 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 180 |
| Start date | 30 January 2025 |
| Primary completion | 1 June 2029 |
| Estimated completion | 1 June 2030 |
| Sites | 2 locations across United States |
Drugs / interventions tested
- Transcranial magnetic stimulation — full drug profile →
Conditions studied
- Major Depressive Disorder — all drugs for Major Depressive Disorder →
- Obsessive-Compulsive Disorder — all drugs for Obsessive-Compulsive Disorder →
- Schizophrenia — all drugs for Schizophrenia →
- Generalized Anxiety Disorder — all drugs for Generalized Anxiety Disorder →
Sponsor
Brigham and Women's Hospital
Who can join
Adults 18 to 65, any sex, with Major Depressive Disorder or Obsessive-Compulsive Disorder. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Participants will receive Transcranial Magnetic Stimulation (TMS) at a random location in the left prefrontal cortex, excluding sites that are potentially unsafe. Extensive behavioral testing will be conducted to determine which behaviors are modulated by stimulating which circuits.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effects of focal brain damage on political behaviour across different political ideologies.
Siddiqi SH, Balters S, Zamboni G, Cohen-Zimerman S, et al · · 2025 · cited 1× · PMID 40117387 · DOI 10.1093/brain/awaf101
Verify or expand the search:
- PubMed search for NCT06376734
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Brigham and Women's Hospital trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06376734 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 21 May 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Brigham and Women's Hospital
- Last refreshed: 17 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06376734.