NCT06335641 (COOLHEAD-2a) is a NA clinical trial of External active conductive head cooling in Stroke, Acute, sponsored by University of Calgary.

Who is sponsoring NCT06335641?

NCT06335641 is sponsored by University of Calgary.

What drugs are being tested in NCT06335641?

Interventions in NCT06335641: External active conductive head cooling.

What condition does NCT06335641 study?

NCT06335641 studies Stroke, Acute.

Is NCT06335641 still recruiting?

NCT06335641 is currently active, enrolled. Last updated 30 December 2024.

Last reviewed 2024-12-30 · How we verify

NCT06335641: COOLHEAD-2a

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Head COOLing in IscHemic Stroke Patients Undergoing EndovAscular Thrombectomy: a Feasibility and Safety StuDy

Active, enrolled NA Last updated 30 December 2024

What this trial tests

NA trial testing External active conductive head cooling in Stroke, Acute in 40 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

28 July 2024

Primary endpoint
24 November 2024

24 February 2025

Quick facts

Lead sponsor	University of Calgary
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	40
Start date	28 July 2024
Primary completion	24 November 2024
Estimated completion	24 February 2025
Sites	2 locations across New Zealand, Canada

Drugs / interventions tested

External active conductive head cooling

Conditions studied

Stroke, Acute — all drugs for Stroke, Acute →

Sponsor

University of Calgary

Who can join

18 and older, any sex, with Stroke, Acute. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is an investigator-initiated, prospective, open-label, single-arm, non-randomized study to assess the safety and feasibility of external active conductive head cooling during endovascular thrombectomy procedures.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Non-invasive convective head cooling during stroke thrombectomy: A prospective multi-center feasibility trial.
Diprose WK, Veilleux C, Almekhlafi M, Beresford A, et al · · 2026 · PMID 41614511 · DOI 10.1093/esj/23969873251371001
Non-invasive convective head cooling during stroke thrombectomy: A prospective multi-center feasibility trial.
Diprose WK, Veilleux C, Almekhlafi M, Beresford A, et al · · 2025 · PMID 40991419 · DOI 10.1177/23969873251371001

Verify or expand the search:

Other recruiting trials for Stroke, Acute

Currently open trials in the same condition.

NCT06825897 — Delay AvoIding Primary Evaluation for ThRombectomy of Acute StrokE Patients With Large Vessel OCclusion in the Angiograp · NA · recruiting
NCT06658197 — Efficacy and Safety of Tenecteplase Bridging Mechanical Thrombectomy for Acute Large Vessel Occlusion Stroke · Phase 3 · recruiting
NCT07253870 — Comperative Effects of Transcutaneous Auricular and Cervical Vagus Nerve Stimulation in Subacute Stroke Patients · NA · recruiting
NCT06941753 — Off-script Diagnosis & Differential Diagnosis (D&D) Training and Residents' Stroke Knowledge · NA · recruiting
NCT06123650 — Post Stroke Dysphagia: Effect of Adding rTMS to Conventional Therapy on the Prevalence of Pneumonia. · NA · recruiting

Other University of Calgary trials

Trials by the same sponsor.

NCT06885996 — Psilocybin-assisted Therapy for Post-Traumatic Stress Disorder in Survivors of Intimate Partner Violence · Phase 2 · not yet recruiting
NCT05729503 — Effect of SPG Block for Patients With Anxiety at Electronic Dance Music Festivals · Phase 2 · not yet recruiting
NCT07463339 — Microbiome-guided Prophylaxis to Reduce Ventilator-Associated Pneumonia in Intensive Care Units: A Pilot Randomized Cont · Phase 2 · not yet recruiting
NCT07145645 — Topical Diclofenac vs.Oral Ibuprofen for MSK Pain in Children · Phase 3 · recruiting
NCT07280325 — Moxie Self-Management and Education Support Program · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06335641 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Calgary
Last refreshed: 30 December 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06335641.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing