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NCT06241651: CSP-UPGRADE
CSP Versus BiVP for Heart Failure Patients with RVP Upgraded to Cardiac Resynchronization Therapy
NA trial testing Conduction system pacing in Conduction System Pacing in 66 participants. Currently enrolling.
1 March 2026
Quick facts
| Lead sponsor | The First Affiliated Hospital with Nanjing Medical University |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 66 |
| Start date | 1 January 2024 |
| Primary completion | 1 March 2026 |
| Estimated completion | 1 March 2026 |
| Sites | 1 location across China |
Drugs / interventions tested
- Conduction system pacing
- Biventricular pacing
Conditions studied
- Conduction System Pacing — all drugs for Conduction System Pacing →
- Biventricular Pacing — all drugs for Biventricular Pacing →
- Cardiac Resynchronization Therapy — all drugs for Cardiac Resynchronization Therapy →
- Right Ventricular Pacing — all drugs for Right Ventricular Pacing →
Sponsor
The First Affiliated Hospital with Nanjing Medical University
Who can join
Adults 18 to 80, any sex, with Conduction System Pacing or Biventricular Pacing. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The present study is a prospective, multicenter, non-inferiority, randomized controlled trail. It aims to investigate whether the efficacy of conduction system pacing (CSP) is non-inferior to biventricular pacing (BiVP) in patients with heart failure and right ventricular pacing (RVP) requiring upgrading to cardiac resynchronization therapy (CRT).
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Is Conduction System Pacing a Valuable Alternative to Biventricular Pacing for Cardiac Resynchronization Therapy?
Castagno D, Zanon F, Pastore G, De Ferrari GM, et al · · 2024 · cited 2× · PMID 38786966 · DOI 10.3390/jcdd11050144
Verify or expand the search:
- PubMed search for NCT06241651
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Conduction system pacing
Trials testing the same drug.
- NCT07276490 — Central Haemodynamics and Pacing for AV Block · NA · recruiting
- NCT07430553 — Comparing Three Types of Specialist Pacemakers to Improve Heart Function and Reduce Rhythm Problems in Heart Failure · NA · recruiting
- NCT06197503 — Randomized Study of Physiological vs Right Ventricular Pacing in Patients With Normal Ventricular Function Post TAVI · NA · recruiting
- NCT06088927 — Long-term Outcomes of Conduction System Pacing: a National Multicenter Observational Study - NORMAND'HIS / STIMU'HIS · recruiting
- NCT05572736 — Conduction System Pacing Versus Biventricular Resynchronization in Patients With Chronic Heart Failure · NA · completed
Other recruiting trials for Conduction System Pacing
Currently open trials in the same condition.
- NCT07276139 — PACEVALUE: Development of a Risk Score to Predict Pacing-Induced Cardiomyopathy in Patients Undergoing Pacemaker or ICD · active not recruiting
- NCT07276490 — Central Haemodynamics and Pacing for AV Block · NA · recruiting
- NCT07217392 — Left Bundle Branch Area Pacing (LBBAP) PMCF Study · NA · recruiting
- NCT06488989 — Left Bundle Branch Area Pacing in Patients With Heart Failure · NA · active not recruiting
- NCT07464041 — Left Bundle Branch Area Pacing Versus Right Ventricular Pacing in Atrioventricular Block With Preserved Ejection Fractio · NA · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06241651 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The First Affiliated Hospital with Nanjing Medical University
- Last refreshed: 12 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06241651.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing