NCT06178822 (BIOSEP) is a clinical trial of No intervention in Sepsis, sponsored by Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC).

What drugs are being tested in NCT06178822?

Interventions in NCT06178822: No intervention.

What condition does NCT06178822 study?

NCT06178822 studies Sepsis, Septic Shock, Sepsis, Severe, Infections, Infection Viral, Infection, Bacterial, Infections, Respiratory.

Is NCT06178822 still recruiting?

NCT06178822 is currently recruiting now. Last updated 2 October 2025.

Last reviewed 2025-10-02 · How we verify

NCT06178822: BIOSEP

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Towards Novel BIOmarkers to Diagnose SEPsis on the Emergency Room

Recruiting now Last updated 2 October 2025

What this trial tests

trial testing No intervention in Sepsis in 3,300 participants. Currently enrolling.

Timeline

25 October 2022

Primary endpoint
1 October 2026

1 October 2026

Quick facts

Lead sponsor	Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC)
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	3,300
Start date	25 October 2022
Primary completion	1 October 2026
Estimated completion	1 October 2026
Sites	3 locations across Netherlands

Drugs / interventions tested

No intervention

Conditions studied

Sepsis — all drugs for Sepsis →
Septic Shock — all drugs for Septic Shock →
Sepsis, Severe — all drugs for Sepsis, Severe →
Infections — all drugs for Infections →

Sponsor

Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC)

Who can join

18 and older, any sex, with Sepsis or Septic Shock. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Objectives: 1. To compare the immune response of patients with or without sepsis presenting to the ED with a(n) (suspected) infection. 2. To determine immune response aberrations that are associated with an increased risk of developing sepsis in patients presenting to the ED with a(n) (suspected) infection without sepsis. 3. To determine the long term cognitive and physical sequelae of sepsis after admission.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Biomarkers to guide sepsis management.
Bourika V, Rekoumi EA, Giamarellos-Bourboulis EJ. · · 2025 · cited 5× · PMID 40685448 · DOI 10.1186/s13613-025-01524-1
Towards novel BIOmarkers to diagnose SEPsis (BIOSEP) in the emergency room: a protocol for a multicentre, prospective cohort study.
Reijnders E, Turgman O, Joosten SCM, Schinkel M, et al · · 2025 · PMID 40750284 · DOI 10.1136/bmjopen-2025-103138

Verify or expand the search:

Other trials of No intervention

Trials testing the same drug.

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Other recruiting trials for Sepsis

Currently open trials in the same condition.

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NCT07351344 — African Survey on Sepsis Knowledge (ASK) · recruiting
NCT07448805 — Accuracy and Safety of the Syai Tag System for Continuous Glucose Monitoring in Intensive Internal Care Unit · NA · recruiting

Other Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC) trials

Trials by the same sponsor.

NCT07165145 — Effect of Agricultural Practices on Crops, Gut Microbiome, and Human Health · NA · recruiting
NCT06079970 — Confocal Laser Endomicroscopy VERification · NA · recruiting
NCT05917067 — Fluorescence Imaging of the Parathyroid Glands of Children · completed
NCT05686330 — Detection and Quantification of Atrial Fibrillation in High-risk Patients Using a Smartwatch Wearable (Apple Watch) · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06178822 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC)
Last refreshed: 2 October 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06178822.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing