Last reviewed · How we verify
NCT06106958: FRAMES
Effects of Foot Rehabilitation And Minimalist Shoes on Pain, Strength, and Function in Adults With Plantar Fasciopathy
NA trial testing Home Exercise Program in Plantar Fascitis in 37 participants. Completed in 20 January 2025.
20 January 2025
Quick facts
| Lead sponsor | University of Virginia |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 37 |
| Start date | 14 February 2024 |
| Primary completion | 20 January 2025 |
| Estimated completion | 20 January 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Home Exercise Program
- Minimalist Shoes
Conditions studied
- Plantar Fascitis — all drugs for Plantar Fascitis →
- Plantar Fasciopathy — all drugs for Plantar Fasciopathy →
- Plantar Fasciitis of Both Feet — all drugs for Plantar Fasciitis of Both Feet →
- Plantar Fasciitis of Right Foot — all drugs for Plantar Fasciitis of Right Foot →
Sponsor
University of Virginia
Who can join
Adults 18 to 55, any sex, with Plantar Fascitis or Plantar Fasciopathy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial is to compare the effects of 8 weeks of foot rehabilitation exercises in conjunction with wearing minimalist shoes in individuals with plantar fasciopathy, compared to only performing foot rehabilitation exercises. The main questions it aims to answer are: * Will individuals with plantar fasciopathy be able to reduce their pain and improve their self-reported function by performing rehabilitation exercises and wearing minimalist shoes, compared to those only performing rehabilitation exercises? * Will individuals with plantar fasciopathy be able to increase their intrinsic foot muscle strength and size, their balance, and gait biomechanics by performing rehabilitation exercises and wearing minimalist shoes, compared to those only performing rehabilitation exercises? * What characteristics of individuals with plantar fasciopathy make them most suited to succeed in a protocol of performing rehabilitation exercises and wearing minimalist shoes? Participants will be asked to come into the lab at the start of the intervention and after 8 weeks, where the following will be assessed: * Patient-reported outcomes * Foot morphology * Intrinsic foot muscle strength * Balance * Gait biomechanics For the intervention, participants in both groups will perform the same rehabilitation exercises, including: * Massage to the bottom of the foot * Calf-raises * Calf and foot stretches
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The effects of performing therapeutic exercises and wearing minimalist shoes on intrinsic foot muscle function and single-leg balance in adults with plantar fasciopathy.
Xu J, Hertel J, Kuenze C, Jaffri AH, et al · · 2026 · PMID 42155155 · DOI 10.1016/j.clinbiomech.2026.106869
Verify or expand the search:
- PubMed search for NCT06106958
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Plantar Fascitis
Currently open trials in the same condition.
- NCT07055698 — Responsiveness And Minimal Clinically Important Difference Of Navicular Height Drop Test With Plantar Fasciitis · active not recruiting
- NCT07037290 — Ankle Proprioceptive Neuromuscular Facilitation Technique Versus Foot Core Exercise in Patients With Plantar Fascitis · NA · active not recruiting
- NCT06536803 — Effects of High Load Strength Training With and Without Tissue Specific Planter Facia Stretching With Planter Fasciitis · NA · recruiting
- NCT06706531 — Additional Effects of Dry Needling With Conventional Physical Therapy Versus Conventional Physical Therapy in Plantar Fa · NA · recruiting
- NCT06466616 — Shock Waves Therapy Combined With Leg Stretching in Patients With Plantar Fasciitis · NA · active not recruiting
Other University of Virginia trials
Trials by the same sponsor.
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- NCT07405645 — Stereotactic MRI-guided Focused Ultrasound Mesencephalotomy · NA · recruiting
- NCT07146685 — Effect of Local Anesthetic Concentration on Rebound Pain: A Randomized Control Study · Phase 4 · not yet recruiting
- NCT07298941 — Resilience Enhancement Following Sleep Treatment · Phase 2 · recruiting
- NCT07036315 — Meaning in Music-Based Pain Modulation · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06106958 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Virginia
- Last refreshed: 16 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06106958.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing