NCT05957822 is a Phase 4 clinical trial of TXA in Arthritis Knee, sponsored by Konkuk University Medical Center.

Who is sponsoring NCT05957822?

NCT05957822 is sponsored by Konkuk University Medical Center.

What drugs are being tested in NCT05957822?

Interventions in NCT05957822: TXA, TEG6.

What condition does NCT05957822 study?

NCT05957822 studies Arthritis Knee, Spine Fusion, Prostate Cancer, Arthritis of Hip, Hepatic Cancer.

Is NCT05957822 still recruiting?

NCT05957822 is currently recruiting now. Last updated 14 May 2024.

Last reviewed 2024-05-14 · How we verify

NCT05957822

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Goal-directed vs Preemptive Tranexamic Acid Administration in Non-cardiac Surgery

Recruiting now Phase 4 Last updated 14 May 2024

What this trial tests

Phase 4 trial testing TXA in Arthritis Knee in 148 participants. Currently enrolling.

Timeline

10 February 2024

Primary endpoint
1 December 2024

1 January 2025

Quick facts

Lead sponsor	Konkuk University Medical Center
Phase	Phase 4
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	148
Start date	10 February 2024
Primary completion	1 December 2024
Estimated completion	1 January 2025
Sites	1 location across South Korea

Drugs / interventions tested

TXA — full drug profile →
TEG6

Conditions studied

Arthritis Knee — all drugs for Arthritis Knee →
Spine Fusion — all drugs for Spine Fusion →
Prostate Cancer — all drugs for Prostate Cancer →
Arthritis of Hip — all drugs for Arthritis of Hip →

Sponsor

Konkuk University Medical Center

Who can join

19 and older, any sex, with Arthritis Knee or Spine Fusion. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The present study is a multi-center randomized prospective non-inferiority trial. The study's primary objective is to compare the coagulation profile upon using two different TXA administration strategies: empirical TXA administration vs. viscoelastic test-based goal-directed TXA administration in high-risk non-cardiac surgery. The secondary objectives include comparing the amount of bleeding, incidents of hyper-fibrinolysis, thromboembolic complications, and postoperative seizures. Researchers assumed that goal-directed tranexamic acid (TXA) administration using viscoelastic field tests would not be inferior to the empirical TXA administration strategy in reducing postoperative bleeding and hyper-fibrinolysis. It also would be beneficial in lowering TXA-induced thromboembolic complications and seizures.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Viscoelastic haemostatic assays to guide therapy in elective surgery: an updated systematic review and meta-analysis.
Dias JD, Levy JH, Tanaka KA, Zacharowski K, et al · · 2025 · cited 6× · PMID 39544008 · DOI 10.1111/anae.16463

Verify or expand the search:

Other trials of TXA

Trials testing the same drug.

NCT06781021 — The Effect of Tranexamic Acid Vs Torniquet on Visual Clarity in Knee Arthroscopic ACL Reconstruction · NA · enrolling by invitation
NCT05138913 — Arthroscopic Treatment Combine With TXA for Elbow Stiffness · NA · unknown

Other recruiting trials for Arthritis Knee

Currently open trials in the same condition.

NCT07391592 — Post Market Clinical Follow-Up Study for EVOLUTION® NitrX™ Keeled Tibia and EVOLUTION® NitrX™ CS/CR Femur With Cruciate · active not recruiting
NCT05290818 — Total Versus Robotic Assisted Unicompartmental Knee Replacement · NA · recruiting
NCT05788016 — Developing an Opioid Taper Intervention Before Total Joint Arthroplasty · NA · recruiting
NCT06821269 — Functional Recovery After Total Knee Arthroplasty · recruiting

Other Konkuk University Medical Center trials

Trials by the same sponsor.

NCT06637943 — Comparison of the Diagnosis Time of VET and SCL in Patients With Intraoperative Coagulopathy · not yet recruiting
NCT06144112 — Fibrinogen Concentrates Versus Cryoprecipitate in Liver Transplant Surgery · Phase 4 · not yet recruiting
NCT06664320 — Mild ANH on Pre-bypass Coagulation Function During Cardiac Surgery · NA · not yet recruiting
NCT06574594 — Effect of MTX Discontinuation on Shingrix Response in RA · NA · recruiting
NCT06144099 — Prothrombin Complex Concentrate vs Fresh Frozen Plasma in Goal-directed Bleeding Management in Non-cardiac Surgery · Phase 4 · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05957822 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Konkuk University Medical Center
Last refreshed: 14 May 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05957822.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing