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NCT05788016
Developing an Opioid Taper Intervention Before Total Joint Arthroplasty
NA trial testing opioid taper in Arthritis Knee in 45 participants. Currently enrolling.
1 July 2026
Quick facts
| Lead sponsor | University of Alabama at Birmingham |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | supportive care |
| Enrollment | 45 |
| Start date | 10 January 2024 |
| Primary completion | 1 July 2026 |
| Estimated completion | 1 September 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- opioid taper
Conditions studied
- Arthritis Knee — all drugs for Arthritis Knee →
- Arthritis Hip — all drugs for Arthritis Hip →
- Chronic Pain — all drugs for Chronic Pain →
Sponsor
University of Alabama at Birmingham
Who can join
18 and older, any sex, with Arthritis Knee or Arthritis Hip. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial is to develop an pharmacist-led preoperative opioid taper intervention for patients undergoing total knee or hip replacement who are on chronic opioids before their surgery. The main questions it aims to answer are: * Is the intervention feasible and acceptable to patients? * Does the intervention result in a decrease in opioid dose during the preoperative period? Participants will meet with a clinical pharmacist, who will provide some basic education on pain and opioids, and will propose an opioid taper schedule. The pharmacist will then follow-up with the participant by phone each week until surgery to assess progress and adjust the taper as necessary.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05788016
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Arthritis Knee
Currently open trials in the same condition.
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- NCT05957822 — Goal-directed vs Preemptive Tranexamic Acid Administration in Non-cardiac Surgery · Phase 4 · recruiting
- NCT06821269 — Functional Recovery After Total Knee Arthroplasty · recruiting
Other University of Alabama at Birmingham trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05788016 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Alabama at Birmingham
- Last refreshed: 29 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05788016.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing