NCT05935280 is a EARLY_PHASE1 clinical trial of Room temperature in Pain, sponsored by Medical University of Vienna.

Who is sponsoring NCT05935280?

NCT05935280 is sponsored by Medical University of Vienna.

What drugs are being tested in NCT05935280?

Interventions in NCT05935280: Room temperature, Cold temperature, Lidocain, PF-05105679, A967079, PF-05089771, PF-06305591.

Is NCT05935280 still recruiting?

NCT05935280 is currently completed. Last updated 15 March 2024.

Last reviewed 2024-03-15 · How we verify

NCT05935280

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Mechanism of Human Cold Pain Perception - Involvement of TRPA1, TRPM8, Nav1.7 and Nav1.8

Completed EARLY_PHASE1 Last updated 15 March 2024

What this trial tests

EARLY_PHASE1 trial testing Room temperature in Pain in 36 participants. Completed in 1 September 2023.

Timeline

7 July 2023

Primary endpoint
1 September 2023

1 September 2023

Quick facts

Lead sponsor	Medical University of Vienna
Phase	EARLY_PHASE1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	single group
Masking	quadruple
Primary purpose	basic science
Enrollment	36
Start date	7 July 2023
Primary completion	1 September 2023
Estimated completion	1 September 2023
Sites	1 location across Austria

Drugs / interventions tested

Room temperature
Cold temperature
Lidocain — full drug profile →
PF-05105679 — full drug profile →
A967079 — full drug profile →
PF-05089771 — full drug profile →
PF-06305591 — full drug profile →

Conditions studied

Pain — all drugs for Pain →

Sponsor

Medical University of Vienna

Who can join

Adults 18 to 70, any sex, with Pain. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Animal studies suggest that the transient receptor potential ion channels TRPM8 and TRPA1 are cold sensors and that sodium channels Nav1.8 and Nav1.7 are essential for detecting pain induced by cold temperatures. This study aims to validate these findings in humans.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Human cold pain: a randomized crossover trial.
Resch FJ, Heber S, Shahi F, Zauner M, et al · · 2025 · cited 2× · PMID 39693244 · DOI 10.1097/j.pain.0000000000003503
Physiological functions and pharmacological targeting of transient receptor potential channels.
Chubanov V, Grimm C, Hill K, Schaefer M, et al · · 2025 · PMID 41118703 · DOI 10.1016/j.pharmr.2025.100089

Verify or expand the search:

Other trials of Room temperature

Trials testing the same drug.

NCT04576806 — Physiological Effects of 38°C vs. 22°C Fluid Therapy in Critically Ill Patients · NA · withdrawn
NCT03136549 — Cuff Inflation-supplemented Videoscope-guided Nasal Intubation · NA · completed
NCT03743207 — Preterm Infants May Better Tolerate Warmer Feeds · NA · completed

Other recruiting trials for Pain

Currently open trials in the same condition.

NCT07533409 — Tactile and Pain Sensory Thresholds and Hand Grip Strength · recruiting
NCT07294092 — Ketamine and Propofol NeuroImaging · EARLY_PHASE1 · recruiting
NCT07290205 — Remimazolam NeuroImaging · EARLY_PHASE1 · recruiting
NCT07487610 — Relationship Between Neuropathic Pain and Geriatric Assessment Parameters in Patients Aged 80 Years and Older · recruiting
NCT07454993 — The Effect of Music During Colonoscopy · NA · recruiting

Other Medical University of Vienna trials

Trials by the same sponsor.

NCT07473401 — Retinal Oxygen Metabolism in Children With Myopia · not yet recruiting
NCT07511400 — The Role of NaV1.8 in Human Pain Models · EARLY_PHASE1 · not yet recruiting
NCT07516990 — Intramuscular Injection of Mashed Parathyroid Tissue Into a Forearm During Thyroid Surgery to Prevent Permanent Postoper · NA · recruiting
NCT07496437 — Is Cross-linked Hyaluronic Acid a Biologic Alternative for Alveolar Ridge Preservation? · NA · not yet recruiting
NCT07290712 — Post-Intensive Care Syndrome - Multicentre Prospective Registry Database of the DACH Region · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05935280 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Medical University of Vienna
Last refreshed: 15 March 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05935280.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing