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NCT05913401
Exercise to Augment TMS in Those With Treatment Resistant Depression
NA trial testing Aerobic Exercise in Treatment Resistant Depression in 30 participants. Participants enrolled and being followed up; not accepting new ones.
30 December 2025
Quick facts
| Lead sponsor | Butler Hospital |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 30 |
| Start date | 1 February 2024 |
| Primary completion | 30 December 2025 |
| Estimated completion | 31 December 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Aerobic Exercise — full drug profile →
- Video Watching
Conditions studied
- Treatment Resistant Depression — all drugs for Treatment Resistant Depression →
Sponsor
Butler Hospital
Who can join
18 and older, any sex, with Treatment Resistant Depression. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Given the growing evidence that aerobic increases cortical excitability and promotes neuroplasticity, the scientific premise for its potential priming effect on the brain is strong. Combining AE with rTMS may produce a neural environment optimized for a robust physiological effect of rTMS, thereby leading to improved depression outcomes. With positive findings, this study would provide preliminary support for an innovative, safe and feasible approach for improving outcomes for this significant public health problem.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05913401
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Aerobic Exercise
Trials testing the same drug.
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- NCT07444333 — Cardiac Output and Fatigue in Friedreich's Ataxia · NA · not yet recruiting
- NCT07182006 — Exercise as Medicine for Pediatric Chronic Pain · NA · not yet recruiting
- NCT07404319 — Effectiveness of Exercise Alone and tDCS+Exercise on Cognitive Function Improvement in Patients With Treatment Resistant · NA · not yet recruiting
- NCT07302204 — Efficacy of Aerobic Exercise Versus Therapeutic Exercises on Exercise-induced Hypoalgesia in Knee Osteoarthritis · NA · recruiting
Other recruiting trials for Treatment Resistant Depression
Currently open trials in the same condition.
- NCT07183748 — Psilocybin Microdosing With Psychotherapy for Treatment-Resistant Depression · Phase 2 · recruiting
- NCT06938841 — Maintenance rTMS for Depression (Maitr-De) · NA · recruiting
- NCT06236711 — Transcranial Direct Current Stimulation (tDCS) as an Adjunctive Treatment for Treatment Resistant Depression (TRD) · NA · active not recruiting
- NCT05774665 — Specialized Pro-resolving Lipid Mediators and Treatment Resistant Depression · Phase 2 · active not recruiting
- NCT06895863 — COpenhagen Magnetic Personalized Accelerated Brain Circuit Therapy for Treatment Resistant Depression · NA · recruiting
Other Butler Hospital trials
Trials by the same sponsor.
- NCT07404618 — Video Intervention for Older Adults With Chronic Pain · NA · not yet recruiting
- NCT06880796 — Mindfulness-Based Therapy for Serious Mental Illness · NA · enrolling by invitation
- NCT07195019 — Women's Wellbeing Study · NA · recruiting
- NCT06657950 — Treatments for Improving Mood in Women Survivors of Interpersonal Violence: A Community-Engaged Study-1.2 · NA · completed
- NCT05180344 — Feasibility, Acceptability, and Preliminary Efficacy of a Novel Personalized Mobile Intervention for Suicide - Open Tria · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05913401 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Butler Hospital
- Last refreshed: 14 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05913401.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing