Last reviewed · How we verify
NCT07404319: TRACE
Effectiveness of Exercise Alone and tDCS+Exercise on Cognitive Function Improvement in Patients With Treatment Resistant Schizophrenia
NA trial testing Aerobic Exercise in Schizophrenia in 160 participants. Not yet recruiting.
30 January 2028
Quick facts
| Lead sponsor | Kit Wa Chan |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | factorial |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 160 |
| Start date | 23 February 2026 |
| Primary completion | 30 January 2028 |
| Estimated completion | 30 January 2028 |
| Sites | 1 location across Hong Kong |
Drugs / interventions tested
- Aerobic Exercise — full drug profile →
- Stretching/Education Control
- Active tDCS
- Sham tDCS
Conditions studied
- Schizophrenia — all drugs for Schizophrenia →
- Treatment Resistant Schizophrenia — all drugs for Treatment Resistant Schizophrenia →
- Cognitive Impairment — all drugs for Cognitive Impairment →
Sponsor
Kit Wa Chan
Who can join
Adults 18 to 60, any sex, with Schizophrenia or Treatment Resistant Schizophrenia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Cognitive impairment is a major determinant of disability in schizophrenia. Aerobic exercise improves global cognition in schizophrenia, particularly working memory and attention/vigilance. Transcranial direct current stimulation (tDCS) targeting frontal regions has shown promise for cognitive deficits, including working memory improvements in some studies. This randomized 2×2 factorial trial will test the independent and combined effects of supervised aerobic exercise and prefrontal tDCS on cognition in treatment resistant schizophrenia, measured using the MATRICS Consensus Cognitive Battery (MCCB).
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07404319
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Aerobic Exercise
Trials testing the same drug.
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- NCT07331077 — A Physical Activity Program Compared to Health Education for Improving Memory and Attention in Hispanic Women With Newly · NA · not yet recruiting
Other recruiting trials for Schizophrenia
Currently open trials in the same condition.
- NCT07424404 — A Study to Evaluate the Long-term Safety and Tolerability of KarXT and KarX-EC for the Treatment of Schizophrenia and Au · Phase 3 · recruiting
- NCT07467993 — Study to Assess the Safety, Tolerability, and Treatment Response of GXV813 in Hospitalized Adults With Schizophrenia · Phase 2 · recruiting
- NCT07379827 — Effectiveness and Adverse-effect Switch Evaluation of Xanomeline and Trospium Chloride (KarXT) · recruiting
- NCT06758414 — CBT-CP for Veterans With SMI · NA · recruiting
- NCT07395206 — Acceptability, Feasibility and Preliminary Outcomes of the Kiso Mind App for Outpatients With Schizophrenia Spectrum Dis · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07404319 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Kit Wa Chan
- Last refreshed: 11 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07404319.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing