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NCT06236711
Transcranial Direct Current Stimulation (tDCS) as an Adjunctive Treatment for Treatment Resistant Depression (TRD)
NA trial testing tDCS in Treatment Resistant Depression in 10 participants. Participants enrolled and being followed up; not accepting new ones.
15 October 2025
Quick facts
| Lead sponsor | Mayo Clinic |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 10 |
| Start date | 20 March 2025 |
| Primary completion | 15 October 2025 |
| Estimated completion | 31 December 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- tDCS — full drug profile →
Conditions studied
- Treatment Resistant Depression — all drugs for Treatment Resistant Depression →
Sponsor
Mayo Clinic
Who can join
18 and older, any sex, with Treatment Resistant Depression. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The researchers are trying to test the feasibility and acceptability of using transcranial Direct Current Stimulation (tDCS) in hospitalized adult patients with Treatment Resistant Depression (TRD), assess for any preliminary effect on depressive and cognitive symptoms, and explore the utility of biomarkers to assess response to tDCS.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Transcranial direct current simulation as an adjunctive treatment for treatment-resistant depression in hospitalized patients: A feasibility study protocol.
Li JW, Ren C, Pazdernik VK, Kung S, et al · · 2025 · PMID 40493630 · DOI 10.1371/journal.pone.0324808
Verify or expand the search:
- PubMed search for NCT06236711
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of tDCS
Trials testing the same drug.
- NCT07400939 — Brain Stimulation Combined With Watching Hand Movements to Improve Hand Recovery in Chronic Stroke · NA · recruiting
- NCT06994390 — Neuropathic Pain Intervention With tDCS in Brazilian Military Personnel (NeuBRAIN Trial) · NA · not yet recruiting
- NCT07358832 — Neuromodulation Through Multisensory Stimulation for Visual Field Deficits in the Subacute Stage of Disease · NA · recruiting
- NCT07331779 — Effect of tDCS Timing on Motor Recovery in Acute Stroke Rehabilitation · NA · not yet recruiting
- NCT06972368 — Home-Based tDCS for Depression in BPD · NA · recruiting
Other recruiting trials for Treatment Resistant Depression
Currently open trials in the same condition.
- NCT07183748 — Psilocybin Microdosing With Psychotherapy for Treatment-Resistant Depression · Phase 2 · recruiting
- NCT06938841 — Maintenance rTMS for Depression (Maitr-De) · NA · recruiting
- NCT05774665 — Specialized Pro-resolving Lipid Mediators and Treatment Resistant Depression · Phase 2 · active not recruiting
- NCT06895863 — COpenhagen Magnetic Personalized Accelerated Brain Circuit Therapy for Treatment Resistant Depression · NA · recruiting
- NCT06132178 — Psilocybin rTMS for Treatment Resistant Depression · Phase 2 · recruiting
Other Mayo Clinic trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06236711 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Mayo Clinic
- Last refreshed: 6 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06236711.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing