Who is sponsoring NCT05857852?

NCT05857852 is sponsored by University of Virginia.

What drugs are being tested in NCT05857852?

Interventions in NCT05857852: Low-Intensity Focused Ultrasound, Sham LIFU device.

What condition does NCT05857852 study?

NCT05857852 studies Cocaine Use Disorder, Cocaine Dependence, Cocaine Abuse, Ultrasound.

Is NCT05857852 still recruiting?

NCT05857852 is currently status unknown. Last updated 15 May 2023.

Last reviewed 2023-05-15 · How we verify

NCT05857852

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Low-Intensity Focused Ultrasound for Cocaine Use Disorder

Status unknown NA Last updated 15 May 2023

What this trial tests

NA trial testing Low-Intensity Focused Ultrasound in Cocaine Use Disorder in 30 participants. Status unknown.

Timeline

1 March 2023

Primary endpoint
1 March 2025

1 March 2025

Quick facts

Lead sponsor	University of Virginia
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	triple
Primary purpose	health services research
Enrollment	30
Start date	1 March 2023
Primary completion	1 March 2025
Estimated completion	1 March 2025
Sites	1 location across United States

Drugs / interventions tested

Low-Intensity Focused Ultrasound
Sham LIFU device

Conditions studied

Cocaine Use Disorder — all drugs for Cocaine Use Disorder →
Cocaine Dependence — all drugs for Cocaine Dependence →
Cocaine Abuse — all drugs for Cocaine Abuse →
Ultrasound — all drugs for Ultrasound →

Sponsor

University of Virginia

Who can join

18 and older, any sex, with Cocaine Use Disorder or Cocaine Dependence. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study aims to understand the role of Low-Intensity Focused Ultrasound on craving levels for cocaine as evidenced by diagnostic imaging of the dorsal anterior insula (dAI) and subjective ratings. Data analysis will serve to show if 1) LIFU is safe and effective and to 2) examine the effects of LIFU on dAI BOLD activity and craving in response to cocaine cue-exposure. The study will screen 60 individuals with Cocaine Use Disorder (CUD) to arrive at 30 enrolled subjects, based on a 2:1 screen/randomization ratio.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Transcranial Ultrasound Stimulation as an Emerging Treatment for Substance use Disorder: Promise and Precaution.
Komarnyckyj M, Sherpa NN, Lawn W, Fouragnan E. · · 2026 · PMID 42079841 · DOI 10.1007/s40429-026-00734-2
Emerging neuromodulation treatments for opioid and stimulant use disorders.
Howard SD, Qiu L, Hager N, Childress AR, et al · · 2025 · PMID 41164146 · DOI 10.3389/fnhum.2025.1570555

Verify or expand the search:

Other trials of Low-Intensity Focused Ultrasound

Trials testing the same drug.

NCT06496971 — A Prospective Pivotal Study to Evaluate the Efficacy and Safety of Avastin® Bevacizumab (BEV) With or Without Microbubbl · Phase 3 · recruiting
NCT04306601 — Low-Intensity Focused Ultrasound on Individuals With Disorder of Consciousness of Traumatic Brain Injury · NA · completed

Other recruiting trials for Cocaine Use Disorder

Currently open trials in the same condition.

NCT07227948 — Repurposing Semaglutide for the Treatment of Cocaine Use Disorder · Phase 2 · recruiting
NCT07086794 — Cocaine and Pentoxifylline (BED IN 47) · EARLY_PHASE1 · recruiting
NCT06050304 — CRACK-TARGET 1: Descriptive Study of Observed Behavioral Sensitization and Expectations · NA · recruiting
NCT07091877 — Cocaine Cue-reactivity Incubation Study · NA · recruiting
NCT05986578 — Identifying Electrophysiological Targets for Transcranial Magnetic Stimulation in Cocaine Use Disorder · NA · recruiting

Other University of Virginia trials

Trials by the same sponsor.

NCT05880355 — Multimodality Cardiovascular Imaging for the Translation of Therapies for Vascular Activation After MI · EARLY_PHASE1 · not yet recruiting
NCT07405645 — Stereotactic MRI-guided Focused Ultrasound Mesencephalotomy · NA · recruiting
NCT07146685 — Effect of Local Anesthetic Concentration on Rebound Pain: A Randomized Control Study · Phase 4 · not yet recruiting
NCT07298941 — Resilience Enhancement Following Sleep Treatment · Phase 2 · recruiting
NCT07036315 — Meaning in Music-Based Pain Modulation · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05857852 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Virginia
Last refreshed: 15 May 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05857852.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing