NCT05847985: LANG-LBD

Language and Lewy Body Diseases: Sentence Comprehension Problems and Modifying Noninvasive Brain Stimulation Treatment

Recruiting now NA Last updated 4 February 2026

What this trial tests

NA trial testing transcranial direct current stimulation (tDCS) in Lewy Body Disease in 90 participants. Currently enrolling.

Timeline

1 May 2023

Primary endpoint
31 December 2026

31 December 2026

Quick facts

Lead sponsor	Masaryk University
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	supportive care
Enrollment	90
Start date	1 May 2023
Primary completion	31 December 2026
Estimated completion	31 December 2026
Sites	1 location across Czechia

Drugs / interventions tested

• transcranial direct current stimulation (tDCS)

Conditions studied

• Lewy Body Disease — all drugs for Lewy Body Disease →
• Healthy Aging — all drugs for Healthy Aging →

Sponsor

Masaryk University

Who can join

Adults 60 to 80, any sex, with Lewy Body Disease or Healthy Aging. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Lewy body diseases (LBDs) represents a group of neurodegenerative disorders characterized by the abnormal accumulation of aggregates of α-synuclein protein leading to the formation of Lewy bodies (LB) and Lewy neurites resulting in cell death. LBDs consists of two major clinical entities - Parkinson's disease (PD) and dementia with LB (DLB). Vast majority of patients with LBDs either already have mild cognitive impairment (MCI) at the time of the diagnosis or will develop it during the course of the disease. Language dysfunctions in LBDs patients with MCI are often unrecognized, which are difficult to treat, but even subtle changes might lead to impairment of social and occupational functioning with profound effect on their quality of lives. Current pharmacological or surgical strategies are effective for tackling the motor issues of LBDs with very limited effects on other symptoms such as language dysfunctions. Therefore, non-pharmacological approaches are gaining more attention. One of these non-pharmacological strategies is the use of noninvasive brain stimulation (NIBS) techniques that are able to modulate the brain functions with the effects on human nervous system plasticity. In this proposed project the investigators aim to first describe specific alterations in the language domain in LBDs patients with MCI as compared to healthy controls (HC) and identify the neural underpinnings of these changes using novel combination of advanced multimodal imaging techniques and various analytical methods. Secondly, the investigators aim to use NIBS as a supervised and individualized home-based therapeutical approach to tackle the language dysfunctions.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.