Last reviewed · How we verify
NCT05753631
Effects of i-PRF on Non-surgical Periodontal Treatment
trial testing non surgical periodontal treatment in Platelet-Rich Fibrin in 24 participants. Completed in 15 January 2023.
15 November 2022
Quick facts
| Lead sponsor | Pamukkale University |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 24 |
| Start date | 2 February 2022 |
| Primary completion | 15 November 2022 |
| Estimated completion | 15 January 2023 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- non surgical periodontal treatment
Conditions studied
- Platelet-Rich Fibrin — all drugs for Platelet-Rich Fibrin →
Sponsor
Pamukkale University
Who can join
Adults 18 to 65, any sex, with Platelet-Rich Fibrin. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Injectable platelet-rich fibrin, a platelet concentrate in a liquid formulation, has been developed to provide clinicians with ease of use alone or in combination with various biomaterials. The low-speed centrifugation method provides a significant advantage to the regeneration process with richer platelets, leukocytes, and growth factors. It also contributes to the wound-healing process by increasing vascularization. It is expected that the application of injectable platelet-rich fibrin into the gingival pocket following subgingival curettage in periodontitis patients will positively affect the results of non-surgical periodontal treatment. For this reason, in this study it was aimed to investigate the early effects of injectable PRF applied into the pocket for root surface biomodification following subgingival curettage in periodontal pockets of 6 mm and above, by evaluating both clinical parameters and inflammatory and healing markers in the gingival groove fluid
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Efficacy of injectable platelet-rich fibrin on clinical and biochemical parameters in non-surgical periodontal treatment: a split-mouth randomized controlled trial.
Torumtay Cin G, Lektemur Alpan A, Çevik Ö. · · 2023 · cited 7× · PMID 38153510 · DOI 10.1007/s00784-023-05447-8
Verify or expand the search:
- PubMed search for NCT05753631
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of non surgical periodontal treatment
Trials testing the same drug.
- NCT04051385 — Assesment of Gingival Crevicular Fluid and Serum ErbB4/Neuregulin-4 Levels in Periodontal Disease and Health · NA · completed
- NCT03919006 — Netrin 1 and Its Receptor Unc5b as Markers of Periodontal Disease · NA · completed
Other recruiting trials for Platelet-Rich Fibrin
Currently open trials in the same condition.
- NCT06679283 — Surgical Treatment of Peri-implantitis With Adjunctive Application of Platelet Rich Fibrin (PRF) · NA · recruiting
Other Pamukkale University trials
Trials by the same sponsor.
- NCT06667856 — Foot Core Exercise Training With Telerehabilitation · NA · suspended
- NCT07532499 — EMG-Triggered Electrical Stimulation After Median/Ulnar Nerve Repairs · NA · not yet recruiting
- NCT07473232 — Comparison of Platelet-rich Plasma and Activated Cytokine-rich Serum Injection Treatments in Patients With Knee Osteoart · NA · not yet recruiting
- NCT07520084 — Predictors of Climate Change Health Literacy in Older Individuals · recruiting
- NCT07388316 — Functional Improvement and Fine Dexterity in Thumb Tendon Injuries · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05753631 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Pamukkale University
- Last refreshed: 3 March 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05753631.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing