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NCT05742789
Effect of Anesthetics on Troponin I and С-reactive Protein
Phase 1 trial testing Propofol in Mitral Valve Insufficiency in 255 participants. Completed in 9 January 2023.
4 January 2023
Quick facts
| Lead sponsor | Astana Medical University |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | other |
| Enrollment | 255 |
| Start date | 30 November 2021 |
| Primary completion | 4 January 2023 |
| Estimated completion | 9 January 2023 |
| Sites | 1 location across Kazakhstan |
Drugs / interventions tested
- Propofol (Propofol) — full drug profile →
- Isoflurane (ISOFLURANE) — full drug profile →
- Sevoflurane — full drug profile →
Conditions studied
- Mitral Valve Insufficiency — all drugs for Mitral Valve Insufficiency →
- Aortic Valve Insufficiency — all drugs for Aortic Valve Insufficiency →
- Cardiac Disease — all drugs for Cardiac Disease →
Sponsor
Astana Medical University
Who can join
Adults 50 to 65, any sex, with Mitral Valve Insufficiency or Aortic Valve Insufficiency. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Abstract Troponin is one of the cardiac biomarkers and its high level correlates to high risk of cardiac myocytes damage. C-reactive protein (CRP) in cardiosurgery participates in the Systemic Inflammation Response Syndrome, and heart-lung apparatus is a powerful stimulator of the systemic inflammatory reaction. Objective: To assess effect of anesthetics on troponin I and СRP in mitral, tricuspid and aortic valve replacement/plastic in adult. Methods. Single-center prospective randomized controlled clinical study. A total of 95 patients were assigned randomly into three groups according to the type of anesthesia: the first group of 32 patients with propofol, the second group with sevoflurane - 32 patients, and the last - 31 patients were with isoflurane. Levels of the cardiac troponin I were calculated in ng/ml с using a portable fluorometric analyzer I-CHROMAII, manufacture of BoditechMedInc (South Korea). Normal range: \<0.04 ng/ml. CRP concentration in plasma has been determined using a biochemical analyzer Biosystems BA-200 (Spanish company, Barcelona) according to the manufacturer's instructions. The normal level of CRP is less than 5 mg/l.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05742789
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
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Other recruiting trials for Mitral Valve Insufficiency
Currently open trials in the same condition.
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- NCT05927441 — DragonFly EU Pivotal Study · NA · recruiting
- NCT04343313 — The Half Moon Transcatheter Mitral Valve Repair (TMVr) Pilot Study · NA · recruiting
- NCT04153292 — The ENCIRCLE Trial · NA · recruiting
Other Astana Medical University trials
Trials by the same sponsor.
- NCT07038213 — Study of Genome-associated Mechanisms of Diabetic Nephropathy and Evaluation of Nephroprotective Therapy in Patients Wit · enrolling by invitation
- NCT07517497 — The Course of Acute Respiratory Failure in Geriatric Patients With Hip Fracture Using Different Modes of a Vibroacoustic · NA · recruiting
- NCT05693428 — Influence of Anesthetics on Clinical Outcome During Cardiac Surgery in Adults · NA · completed
- NCT05143372 — Influence of Vibroacoustic Therapy Modes on the Course of Coronavirus Infection · NA · completed
- NCT05695287 — The Effects of Sevoflurane, Isoflurane and Propofol During Cardiac Surgery · Phase 1 · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05742789 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Astana Medical University
- Last refreshed: 5 June 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05742789.
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