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NCT05722951
Metformin Efficacy and Safety in Epileptic Patients
Phase 3 trial testing Levetiracetam &/or sodium valproate in Epilepsy in 60 participants. Completed in 20 June 2024.
20 June 2024
Quick facts
| Lead sponsor | Tanta University |
|---|---|
| Phase | Phase 3 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 18 October 2022 |
| Primary completion | 20 June 2024 |
| Estimated completion | 20 June 2024 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Levetiracetam &/or sodium valproate — full drug profile →
- Metformin (metformin) — full drug profile →
Conditions studied
- Epilepsy — all drugs for Epilepsy →
Sponsor
Tanta University
Who can join
Adults 18 to 65, any sex, with Epilepsy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial is to Evaluating Metformin Efficacy and Safety when Co-administered with Antiepileptic Drugs in Patients with Seizures. The main question it aims to answer is: * Does metformin have beneficial effect on epileptic patients? * How metformin can affect epileptic patient's health? Participants will be divided into 2 groups (control group and treatment group) * Control group will receive standard treatment (levetiracetam \&/or sodium valproate). * Treatment group will receive standard treatment (levetiracetam \&/or sodium valproate) + metformin
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Metformin Repurposing in Neurological Disorders: A Clinical Trial Landscape.
R Y, Sharma S, C M, Rangari GM, et al · · 2026 · PMID 41930282 · DOI 10.1177/09727531261421807
Verify or expand the search:
- PubMed search for NCT05722951
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Epilepsy
Currently open trials in the same condition.
- NCT07095933 — The Safety and Efficacy Evaluation of Everolimus as an Adjunctive Treatment for Focal Refractory Epilepsy · EARLY_PHASE1 · recruiting
- NCT07224191 — Hippocampal Oscillations During Exploration · NA · recruiting
- NCT07219407 — A Long-term Study of the Safety and Effectiveness of RAP-219 in Adults With Focal Onset Seizures · Phase 2 · recruiting
- NCT07417280 — LIFUS For Neurological Disorders · NA · recruiting
- NCT07490769 — Levetiracetam Three Times Daily in Epilepsy · Phase 3 · recruiting
Other Tanta University trials
Trials by the same sponsor.
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- NCT07334197 — Effect of Melatonin on Left Ventricular Reverse Remodeling and Inflammation in Peripartum Cardiomyopathy · NA · not yet recruiting
- NCT07498998 — Glucocorticoid, Ozone and 5% Dextrose Local Injection for Pain Relief in Carpal Tunnel Syndrome · NA · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05722951 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Tanta University
- Last refreshed: 2 December 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05722951.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing