Last reviewed · How we verify
NCT05664854: EITsVNS
Electrical Impedance Tomography & Selective Stimulation of Vagus Nerve
NA trial testing Nerve cuff electrodes for spatially selective vagus nerve stimulation and electrical impedance tomography in Vagus Nerve Diseases in 50 participants. Currently enrolling.
31 January 2025
Quick facts
| Lead sponsor | University College, London |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 50 |
| Start date | 4 December 2023 |
| Primary completion | 31 January 2025 |
| Estimated completion | 31 January 2027 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Nerve cuff electrodes for spatially selective vagus nerve stimulation and electrical impedance tomography
Conditions studied
- Vagus Nerve Diseases — all drugs for Vagus Nerve Diseases →
- Epilepsy — all drugs for Epilepsy →
- Vagus Nerve Autonomic Disorder — all drugs for Vagus Nerve Autonomic Disorder →
Sponsor
University College, London
Who can join
18 and older, any sex, with Vagus Nerve Diseases or Epilepsy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Electroceuticals is a new field in which the goal is to treat a wide variety of medical diseases with electrical stimulation of autonomic nerves. A prime target for intervention is the cervical vagus nerve as it is easily surgically accessible and supplies many organs in the neck, thorax and abdomen. It would be desirable to stimulate selectively in order to avoid the off-target effects that currently occur. This has not been tried in the past, both because of limitations in available technology but also because, surprisingly, the fascicular organisation of the cervical vagus nerve is almost completely unknown. The aim of this research is to investigate the functional anatomy of fascicles in the cervical vagus nerve of humans. This will include defining innervation to the heart, lungs and recurrent laryngeal and, if possible, the oesophagus, stomach, pancreas, liver and gastrointestinal tract. It will be achieved by defining fascicle somatotopic functional anatomy with spatially-selective vagus nerve stimulation (sVNS) and the new method of fast neural imaging with Electrical Impedance Tomography (EIT). EIT is a novel imaging method in which reconstructed tomographic images of resistance changes related to the opening of ion channels over milliseconds can be produced using rings or arrays of external electrodes. In humans, using a nonpenetrating nerve cuff with sVNS or fast neural EIT, this will be performed for 30 minutes transiently during an operation to insert a vagal nerve stimulator for treatment of epilepsy and deliver images in response to activity such as respiration or the electrocardiogram (ECG).
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05664854
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
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Related trials
Other University College, London trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05664854 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University College, London
- Last refreshed: 9 August 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05664854.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing