Who is sponsoring NCT06924086?

NCT06924086 is sponsored by University College, London.

What drugs are being tested in NCT06924086?

Interventions in NCT06924086: Deep Brain Stimulation.

What condition does NCT06924086 study?

NCT06924086 studies Lennox Gastaut Syndrome (LGS).

Is NCT06924086 still recruiting?

NCT06924086 is currently recruiting now. Last updated 7 April 2026.

Last reviewed 2026-04-07 · How we verify

NCT06924086: CADET

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Children's Adaptive Deep Brain Stimulation for Epilepsy Trial

Recruiting now NA Last updated 7 April 2026

What this trial tests

NA trial testing Deep Brain Stimulation in Lennox Gastaut Syndrome (LGS) in 22 participants. Currently enrolling.

Timeline

24 March 2026

Primary endpoint
31 January 2028

31 January 2028

Quick facts

Lead sponsor	University College, London
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	22
Start date	24 March 2026
Primary completion	31 January 2028
Estimated completion	31 January 2028
Sites	1 location across United Kingdom

Drugs / interventions tested

Deep Brain Stimulation

Conditions studied

Lennox Gastaut Syndrome (LGS) — all drugs for Lennox Gastaut Syndrome (LGS) →

Sponsor

University College, London

Who can join

Adults 5 to 14, any sex, with Lennox Gastaut Syndrome (LGS). Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The CADET Trial will investigate the effectiveness of deep brain stimulation (DBS) to reduce the frequency of seizures in children with Lennox-Gastaut syndrome (LGS). The CADET Trial will use a non-CE/UKCA marked device - the Picostim DBS system. The SMART-DBS study is a sub-study of the CADET Trial. SMART-DBS will investigate the application of adaptive DBS for the treatment of children with LGS. Children will be recruited after they exit from either the prior 'CADET Pilot Study' or 'CADET Trial' - meaning that these children will already be receiving therapy with an already implanted Picostim device.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Clinical trials of surgical neuromodulation therapies for epilepsy: Past, present & future.
Piper RJ, Tisdall MM. · · 2026 · PMID 42214900 · DOI 10.1016/j.neurot.2026.e00935

Verify or expand the search:

Other trials of Deep Brain Stimulation

Trials testing the same drug.

NCT07369401 — Deep Brain Stimulation of the Nucleus Accumbens and Anterior Limb of the Internal Capsule in the Treatment of Refractory · NA · not yet recruiting
NCT07214467 — Individualized Adaptive Deep Brain Stimulation in Opioid Use Disorder · NA · recruiting
NCT06991335 — VC/VS for Apathy in PD · NA · not yet recruiting
NCT07049003 — Deep Brain Stimulation of the Deep Cerebellar Nuclei for Refractory Tremor · Phase 1 · recruiting
NCT07216222 — K08 VR Fear Conditioning · NA · enrolling by invitation

Other University College, London trials

Trials by the same sponsor.

NCT07386652 — Intensive Comprehensive Aphasia Programme for People With Post-Stroke Aphasia · NA · not yet recruiting
NCT07386678 — Study of Imaging and Molecular Biomarkers in Uncomplicated Rhegmatogenous Retinal Detachment · not yet recruiting
NCT07414940 — ACTinium in Castrate-RESistant Prostate Cancer After LUTEtium · Phase 1, PHASE2 · not yet recruiting
NCT07214454 — TCDS for the Treatment of Chronic Migraine · NA · not yet recruiting
NCT06778122 — In-Bedroom Renewed Air as Anti-inflammatory Adjuvant Therapy in Cancer Survivors · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06924086 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University College, London
Last refreshed: 7 April 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06924086.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing