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NCT05602519
The Analgesic Efficacy of Oxycodone Hydrochloride Versus Fentanyl After Total Hip Arthroplasty:
Phase 4 trial testing propofol, rocuronium and fentanyl in Total Hip Arthroplasty in 72 participants. Completed in 30 May 2023.
30 May 2023
Quick facts
| Lead sponsor | Al-Azhar University |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | prevention |
| Enrollment | 72 |
| Start date | 10 November 2022 |
| Primary completion | 30 May 2023 |
| Estimated completion | 30 May 2023 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- propofol, rocuronium and fentanyl — full drug profile →
Conditions studied
- Total Hip Arthroplasty — all drugs for Total Hip Arthroplasty →
- The Analgesic Efficacy — all drugs for The Analgesic Efficacy →
Sponsor
Al-Azhar University
Who can join
Adults 28 to 62, any sex, with Total Hip Arthroplasty or The Analgesic Efficacy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Oxycodone showed similar or superior analgesic effects than fentanyl and was proposed as an alternative for fentanyl for pain control in the postoperative period. However, it was mainly directed to control visceral pain, due to the mediation of analgesic effects by the kappa receptors. However, few studies compared the oxycodone to fentanyl for postoperative pain relief in patients undergoing total hip arthroplasty (replacement). Therefore, we established this randomized study to compare the efficacy of oxycodone and fentanyl for relief of postoperative pain after total hip arthroplasty (replacement).
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Comparison of Effectiveness and Safety of Oxycodone Hydrochloride and Fentanyl for Post-operative Pain Following Total Hip Arthroplasty: A Randomized Triple-Blind Trial.
Kohaf N, Harby SA, Abd-Ellatief AF, Elsaid MA, et al · · 2024 · cited 1× · PMID 38725916 · DOI 10.5812/aapm-142710
Verify or expand the search:
- PubMed search for NCT05602519
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Total Hip Arthroplasty
Currently open trials in the same condition.
- NCT07410000 — Ultrasound-Guided Quadro-Iliac Plane Block for Pain Management After Total Hip Arthroplasty · NA · recruiting
- NCT07227064 — Methadone in THA for Post-op Pain and Opioid Reduction · Phase 3 · recruiting
- NCT06768580 — Effect of Oral Melatonin Versus Intraoperative Lidocaine Infusion on Incidence of Postoperative Delirium in Elderly Pati · NA · recruiting
- NCT06904703 — Pericapsular Nerve Group and Lumbar Erector Spinae Plane Blocks for Geriatrics Undergoing Total Hip Arthroplasty · NA · recruiting
- NCT06356116 — Rehabilitation After Direct Anterior Approach for Total Hip Arthroplasty · NA · recruiting
Other Al-Azhar University trials
Trials by the same sponsor.
- NCT06489327 — Comparing Two Doses of Oral Melatonin as Premedication in Children Undergoing Surgery · NA · recruiting
- NCT07327918 — Effect of Epidural Needle Injection on Catheter Placement Success During Painless Labour · Phase 3 · not yet recruiting
- NCT07500194 — Quad Helix vs RME for Posterior Cross-bite in Egyptian Children · NA · not yet recruiting
- NCT07360756 — Ultrasonographic ONSD as a Predictor of PDPH in Spinal Anesthesia for Cesarean Delivery · not yet recruiting
- NCT07343570 — Comparison of Quadratus Lumborum and Combined Groin Nerve Blocks for Postoperative Analgesia After Open Inguinal Hernia · Phase 3 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05602519 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Al-Azhar University
- Last refreshed: 7 August 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05602519.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing