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propofol, rocuronium and fentanyl
This is a combination of three anesthetic and neuromuscular agents: propofol (GABA agonist for sedation), rocuronium (neuromuscular blocker), and fentanyl (opioid analgesic) used together for anesthesia induction and maintenance.
This is a combination of three anesthetic and neuromuscular agents: propofol (GABA agonist for sedation), rocuronium (neuromuscular blocker), and fentanyl (opioid analgesic) used together for anesthesia induction and maintenance. Used for Induction and maintenance of general anesthesia for surgical procedures, Sedation in intensive care units.
At a glance
| Generic name | propofol, rocuronium and fentanyl |
|---|---|
| Sponsor | Al-Azhar University |
| Drug class | Anesthetic combination (intravenous anesthetic, neuromuscular blocking agent, opioid analgesic) |
| Target | GABA-A receptor (propofol); nicotinic acetylcholine receptor at neuromuscular junction (rocuronium); mu-opioid receptor (fentanyl) |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Propofol enhances inhibitory GABA signaling in the central nervous system to produce rapid sedation and hypnosis. Rocuronium competitively blocks acetylcholine at the neuromuscular junction to provide skeletal muscle paralysis. Fentanyl is a potent mu-opioid receptor agonist that provides analgesia and contributes to sedation. Together, these agents are used as a balanced anesthetic regimen for surgical procedures.
Approved indications
- Induction and maintenance of general anesthesia for surgical procedures
- Sedation in intensive care units
Common side effects
- Hypotension
- Respiratory depression
- Bradycardia
- Injection site pain (propofol)
- Postoperative nausea and vomiting
- Prolonged neuromuscular blockade (rocuronium)
Key clinical trials
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- General Anesthesia and General Anesthesia Combined With Thoracic Epidural Anesthesia (NA)
- qCON/qNOX-Guided Anesthesia in Patients Undergoing Thyroidectomy Surgery (NA)
- Comparison of Airway Management With Bronchial Blocker and Double-Lumen Tube in Single-Lung Ventilation (NA)
- Magnesium Sulfate Versus Other Anesthesia Drugs to Reduce Agitation After Adenotonsillectomy in Pediatric Patients (NA)
- The Effect of the Anticholinergic Burden Following Elective Coronary Artery Surgery (PHASE4)
- Intubation Conditions Achieved With Rapid Co-administration of Rocuronium and Propofol Versus Classical Induction (PHASE4)
- Continuous Versus 1-min Oscillometric Arterial BP Monitoring (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- propofol, rocuronium and fentanyl CI brief — competitive landscape report
- propofol, rocuronium and fentanyl updates RSS · CI watch RSS
- Al-Azhar University portfolio CI