Last reviewed · How we verify
NCT05598086
Anti-fibrinolytic and Anti-inflammatory Effects of Local Infiltration of Tranexamic Acid in Patients With Calcaneal Fractures
NA trial testing Tranexamic acid in Tranexamic Acid in 113 participants. Completed in 15 May 2022.
30 September 2020
Quick facts
| Lead sponsor | Hebei Medical University Third Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 113 |
| Start date | 1 April 2019 |
| Primary completion | 30 September 2020 |
| Estimated completion | 15 May 2022 |
| Sites | 1 location across China |
Drugs / interventions tested
- Tranexamic acid (Tranexamic Acid) — full drug profile →
Conditions studied
- Tranexamic Acid — all drugs for Tranexamic Acid →
- Fibrinolysis — all drugs for Fibrinolysis →
- Inflammatory — all drugs for Inflammatory →
- Fracture — all drugs for Fracture →
Sponsor
Hebei Medical University Third Hospital
Who can join
Adults 18 to 70, any sex, with Tranexamic Acid or Fibrinolysis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Background. Consensus is lacking regarding the use of tranexamic acid (TXA) in calcaneal fracture surgery. This study aims to investigate the hypothesis that local infiltration of TXA in the post-operation would maintain hemoglobin (Hb) level, reduce incision drainage volume and risk of infection in patients with displaced intra-articular calcaneal fractures. Methods. A total of 120 patients with displaced intra-articular calcaneal fractures who received extensible lateral L-shaped approach were included in this trial and equally randomized to receive one single dose of 1g TXA or 1g normal saline after closing incision. The demographic data and fracture characteristics, intra-operative indicators, laboratory tests and Visual Analogue Scale (VAS) scores, incision drainage volume, and incision-related complications were collected and compared between the two groups.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05598086
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Tranexamic acid
Trials testing the same drug.
- NCT07278037 — Trends in the Administration of Tranexamic Acid for Postpartum Hemorrhage · recruiting
- NCT06599762 — Evaluation of Tranexamic Acid in Myelodysplastic Syndromes and Acute Myeloid Leukemia · Phase 2 · recruiting
- NCT06657924 — Preoperative Tranexamic Acid (TXA) to Prevent Bleeding in Patients Undergoing Major Colorectal Surgery · Phase 2 · recruiting
- NCT06806241 — Effects of Tranexamic Acid Irrigation on Impacted Third Molar Surgery · recruiting
- NCT06419075 — Tranexamic Acid in Vaginal Reconstructive Surgery · Phase 4 · withdrawn
Other recruiting trials for Tranexamic Acid
Currently open trials in the same condition.
- NCT07401394 — BAR-TAX - Tranexamic Acid in Bariatric Surgery. · NA · active not recruiting
- NCT07157631 — Efficacy and Safety of Tranexamic Acid in Adult Liver Transplantation---ESTA Trial · NA · recruiting
- NCT06657924 — Preoperative Tranexamic Acid (TXA) to Prevent Bleeding in Patients Undergoing Major Colorectal Surgery · Phase 2 · recruiting
Other Hebei Medical University Third Hospital trials
Trials by the same sponsor.
- NCT06272656 — Evaluation of AKR1B10 as a New Marker for Interventional Therapy of Hepatocellular Carcinoma · recruiting
- NCT06238804 — Characteristic Analysis and Surgical Exploration for Acetabular Roof Fractures: Multicenter Retrospective Cohort Study · withdrawn
- NCT05661227 — Mechanism of Cardiac and Cerebral Function Injury Caused by Intraoperative Limb Ischemia-reperfusion · NA · unknown
- NCT05030259 — The Research About the ACS After Femoropopliteal Arterial Injuries · recruiting
- NCT04891458 — Effect of Intraoperative Sedation on PND in Elderly Patients · NA · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05598086 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hebei Medical University Third Hospital
- Last refreshed: 28 October 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05598086.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing