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NCT06657924
Preoperative Tranexamic Acid (TXA) to Prevent Bleeding in Patients Undergoing Major Colorectal Surgery
Phase 2 trial testing Tranexamic acid in Bleeding in 394 participants. Currently enrolling.
1 September 2026
Quick facts
| Lead sponsor | Kristen Ban |
|---|---|
| Phase | Phase 2 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 394 |
| Start date | 11 February 2025 |
| Primary completion | 1 September 2026 |
| Estimated completion | 1 October 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Tranexamic acid (Tranexamic Acid) — full drug profile →
Conditions studied
- Bleeding — all drugs for Bleeding →
- Colorectal Disorders — all drugs for Colorectal Disorders →
- Thromboembolism — all drugs for Thromboembolism →
- Tranexamic Acid — all drugs for Tranexamic Acid →
Sponsor
Kristen Ban
Who can join
Adults 18 to 100, any sex, with Bleeding or Colorectal Disorders. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this prospective pragmatic randomized clinical trial is to determine if preoperative administration of tranexamic acid (TXA) reduces bleeding during and after major colorectal surgery. The primary questions are: * Does TXA reduce bleeding during and after surgery (change in hemoglobin from before surgery to lowest value after surgery within 30 days) * Does TXA reduce bleeding complications within 30 days of surgery (blood transfusion, return to the operating room or procedural intervention for bleeding, death due to bleeding) * Does TXA increase the risk of thromboembolic complications within 30 days of surgery (cerebrovascular accident, myocardial infarction, deep venous thrombosis, pulmonary embolism) Researchers will compare preoperative TXA to no TXA to answer the above questions. Participants who receive TXA will receive 1 g TXA IV at the beginning and end of surgery in the operating room.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06657924
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Tranexamic acid
Trials testing the same drug.
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- NCT06806241 — Effects of Tranexamic Acid Irrigation on Impacted Third Molar Surgery · recruiting
- NCT06419075 — Tranexamic Acid in Vaginal Reconstructive Surgery · Phase 4 · withdrawn
- NCT06427850 — Effect of Topical Tranexamic Acid on Postoperative Drainage in Minimally Invasive Transforaminal Lumbar Interbody Fusion · NA · not yet recruiting
Other recruiting trials for Bleeding
Currently open trials in the same condition.
- NCT07401394 — BAR-TAX - Tranexamic Acid in Bariatric Surgery. · NA · active not recruiting
- NCT07309848 — Hip Fracture Surgery Timing and Blood Transfusion Risk in Patients on DOACs · recruiting
- NCT07083583 — Impact of IV Iron on Bleeding Symptoms in Iron Deficient Patients With Inherited Bleeding Disorders · recruiting
- NCT07019077 — Incidence of Late Haemorrhage After Invasive Gastroenterological Endoscopic Manoeuvre in Patients Treated With Anticoagu · recruiting
- NCT07358416 — Complications and Antiplatelet and Anticoagulant Therapy in Vascular Surgery. · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06657924 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Kristen Ban
- Last refreshed: 27 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06657924.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing