NCT05505591 (ICARUS) is a clinical trial of Cangrelor in Bleeding, sponsored by Universita degli Studi di Genova.

Who is sponsoring NCT05505591?

NCT05505591 is sponsored by Universita degli Studi di Genova.

What drugs are being tested in NCT05505591?

Interventions in NCT05505591: Cangrelor.

What condition does NCT05505591 study?

NCT05505591 studies Bleeding, Coronary Artery Disease, Myocardial Infarction.

Is NCT05505591 still recruiting?

NCT05505591 is currently status unknown. Last updated 18 August 2022.

Last reviewed 2022-08-18 · How we verify

NCT05505591: ICARUS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Intravenous CAngrelor in High-bleeding Risk Patients Undergoing percutaneouS Coronary Intervention (ICARUS) Registry

Status unknown Last updated 18 August 2022

What this trial tests

trial testing Cangrelor in Bleeding in 900 participants. Status unknown.

Timeline

6 June 2022

Primary endpoint
31 October 2022

31 October 2022

Quick facts

Lead sponsor	Universita degli Studi di Genova
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	900
Start date	6 June 2022
Primary completion	31 October 2022
Estimated completion	31 October 2022
Sites	2 locations across Italy

Drugs / interventions tested

Cangrelor (CANGRELOR) — full drug profile →

Conditions studied

Bleeding — all drugs for Bleeding →
Coronary Artery Disease — all drugs for Coronary Artery Disease →
Myocardial Infarction — all drugs for Myocardial Infarction →

Sponsor

Universita degli Studi di Genova — full company profile →

Who can join

18 and older, any sex, with Bleeding or Coronary Artery Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The study will investigate the prevalence of high bleeding risk (HBR) features and will compare the clinical outcomes of HBR and non-HBR patients among those undergoing percutaneous coronary intervention and receiving cangrelor infusion.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

ICARUS score for predicting peri-procedural bleeding in patients undergoing percutaneous coronary intervention with cangrelor.
Benenati S, Gragnano F, Scalamera R, De Sio V, et al · · 2024 · cited 6× · PMID 39284439 · DOI 10.1016/j.ijcard.2024.132568

Verify or expand the search:

Other trials of Cangrelor

Trials testing the same drug.

NCT06792643 — Cangrelor on Top of anticoagUlation in Patients With myocaRdial Infarction-related Cardiogenic Shock/Cardiac Arrest rece · Phase 2 · recruiting
NCT04667078 — REperfusion With P2Y12 Inhibitors in Addition to mEchanical thRombectomy for perFUsion Imaging Selected Acute Stroke pat · Phase 3 · recruiting
NCT04790032 — Pharmacodynamic Effects of Cangrelor in ACS or CCS Patients Undergoing PCI (POMPEII Registry) · completed
NCT04668144 — Pharmacodynamic and Pharmacokinetic of Switching From Cangrelor to Prasugrel in ACS Patients Undergoing PCI · Phase 4 · completed
NCT04634162 — PD and PK Profiles of Switching Between Cangrelor and Ticagrelor Following Ticagrelor Pre-treatment · Phase 4 · completed

Other recruiting trials for Bleeding

Currently open trials in the same condition.

NCT07401394 — BAR-TAX - Tranexamic Acid in Bariatric Surgery. · NA · active not recruiting
NCT07309848 — Hip Fracture Surgery Timing and Blood Transfusion Risk in Patients on DOACs · recruiting
NCT07083583 — Impact of IV Iron on Bleeding Symptoms in Iron Deficient Patients With Inherited Bleeding Disorders · recruiting
NCT07019077 — Incidence of Late Haemorrhage After Invasive Gastroenterological Endoscopic Manoeuvre in Patients Treated With Anticoagu · recruiting
NCT07358416 — Complications and Antiplatelet and Anticoagulant Therapy in Vascular Surgery. · active not recruiting

Other Universita degli Studi di Genova trials

Trials by the same sponsor.

NCT07481435 — TRacheostomy in DElphi for iNTensive Care' (TRiDENT) · not yet recruiting
NCT07093125 — Rehabilitation Practices in Critically Ill Patients Receiving Invasive Mechanical Ventilation in the Intensive Care Unit · not yet recruiting
NCT07069231 — Effect of Bio-activation on Epithelial and Connective Cell Adhesion to Titanium Abutments: Split Mouth Clinical Trial · NA · not yet recruiting
NCT07094269 — Protocol of the Packer Managing Fatigue Program Versus Standard Information to Improve Energy Conservation Self-Efficacy · NA · recruiting
NCT06378502 — The Effect of Different Antibiotic Protocols on Peri-implant Tissue Health · Phase 4 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05505591 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Universita degli Studi di Genova
Last refreshed: 18 August 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05505591.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing