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NCT05470166: ERAS
Lidocaine Infusion With ERAS Protocol for Pancreatic Cancer Surgery: Effect on Pain and Patient Immunity.
NA trial testing Lidocaine IV in ERAS in 30 participants. Completed in 1 April 2024.
17 January 2024
Quick facts
| Lead sponsor | Alexandria University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | health services research |
| Enrollment | 30 |
| Start date | 20 April 2022 |
| Primary completion | 17 January 2024 |
| Estimated completion | 1 April 2024 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Lidocaine IV — full drug profile →
- saline IV — full drug profile →
Conditions studied
- ERAS — all drugs for ERAS →
- Lidocaine — all drugs for Lidocaine →
- Cancer of Pancreas — all drugs for Cancer of Pancreas →
- Natural Killer Cell Cytokine Production — all drugs for Natural Killer Cell Cytokine Production →
Sponsor
Alexandria University
Who can join
Adults 30 to 70, any sex, with ERAS or Lidocaine. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The whole world now is directed to implement strategies that enhance the patient's quality of life and prevent tumor relapse. Enhanced recovery after pancreatic surgery (ERAPS) program was found to improve the quality of life as it is an evidence-based protocol designed to standardize and optimize perioperative medical care in order to reduce surgical trauma, perioperative physiological stress, organ dysfunction, reduction of clinical complications, length of hospital stay and the health costs together with increase of patient satisfaction. lidocaine; it is an amide local anaesthetic Recently its use as intravenous perioperative infusion for abdominal cancer surgeries is encouraging, as it significantly reduces postoperative pain, opioid consumption and nausea and vomiting. it also promotes gastrointestinal function recovery, and shortens the postoperative hospital stay. In addition, lidocaine in particular can act directly and indirectly on pancreatic cancer cells and the tumor microenvironment. The investigators suggest that IV lidocaine infusion in combination with ERAPS protocol may achieve better postoperative outcomes after pancreatic surgery for cancer.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Neuro-immune crosstalk in cancer: mechanisms and therapeutic implications.
Pu T, Sun J, Ren G, Li H. · · 2025 · cited 34× · PMID 40456735 · DOI 10.1038/s41392-025-02241-8 -
The neuro-immune axis in cancer: from mechanisms to therapeutic opportunities.
Zhang C, Guo X, Liu P, Wang Y, et al · · 2025 · cited 6× · PMID 41152924 · DOI 10.1186/s13045-025-01748-5 -
Trial watch: local anesthetics in cancer therapy.
Carnet Le Provost K, Kepp O, Kroemer G, Bezu L. · · 2024 · cited 5× · PMID 38504848 · DOI 10.1080/2162402x.2024.2308940
Verify or expand the search:
- PubMed search for NCT05470166
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Lidocaine IV
Trials testing the same drug.
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- NCT06243120 — Intravenous Lidocaine for Treating Intrathecal Fentanyl Induced Pruritus · EARLY_PHASE1 · unknown
- NCT06423456 — Postoperative Pain Control Following Hysteroscopy · NA · completed
- NCT06516861 — Magnesium Sulphate and Lidocaine in Hemodynamic Changes and Cortisol Levels · Phase 1 · completed
- NCT06433713 — Effect of Intraoperative Intravenous Lidocaine on Postoperative Pain and Return of Bowel Function After Cesarean Section · Phase 2 · completed
Other recruiting trials for ERAS
Currently open trials in the same condition.
- NCT07276126 — The Effect of the Cesarean ERAS Protocol on Mother-Infant and Father-Infant Bonding: a Multicenter, Randomized Controlle · NA · recruiting
- NCT07210164 — Pre-habilitation Within ERAS Protocol for Gynecologic Oncology Surgery: The Pre_ERAS Study · NA · recruiting
- NCT07116564 — Impact of ERAS Protocol on Length of Hospital Stay After Laparoscopic Surgeries · Phase 4 · recruiting
- NCT07087366 — Enhanced Recovery After Surgery(ERAS) Following Gynaecological Oncology Surgery in a Tertiary Level Hospital · NA · recruiting
- NCT06786819 — Impact of a Technology Platform Based on Enhanced Recovery After(ERAS) Surgery on Length of Stay After Coronary Artery B · NA · recruiting
Other Alexandria University trials
Trials by the same sponsor.
- NCT07517861 — Integrated Mental Health Nursing Program: Effects on Stigma, Cognitive Flexibility, and Clinical Readiness · NA · recruiting
- NCT07476482 — The Impact of a Shared Decision-Making Intervention on Intraoperative Patient Experience During Elective Cesarean Delive · NA · enrolling by invitation
- NCT07476209 — Sialendoscopy Versus Photobiomodulation in Prevention of Radiation Induced Xerostomia · NA · recruiting
- NCT07503626 — Optimization of Orthodontic Bracket Placement by Using Two Different Protocols of Digitally Aided Bonding · NA · recruiting
- NCT07522944 — AI-Guided Relaxation for Hemodialysis Anxiety · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05470166 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Alexandria University
- Last refreshed: 21 August 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05470166.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing